Thursday 30 April 2020

Let’s Talk About the Types of Psoriasis

From healthcentral.com

There are multiple forms of this scaly skin condition, and which one you have will determine the treatment you receive.

With 125 million people in the world who have psoriasis, chances are you know someone who has the condition. But what you may not know is that there are several types of the chronic skin disease. They tend to get lumped in with the most common one: plaque psoriasis, which accounts for a whopping 80% of all cases. But there are six others that look, act, and may even be treated differently than the rest. Knowing which one you have can help you get better, faster.

What Is Psoriasis, Again?

Red, scaly, painful patches or bumps on your skin are the telltale signs of this inflammatory skin condition. It happens when your skin cells turn over at a way-too-fast rate (10 times faster than normal), causing a pile up of cells on the skin’s surface that form those angry, red patches, or plaques. Why this happens isn’t so clear, but researchers believe psoriasis is caused by a mix of genetics, an overactive immune system, and triggers such as bacterial infection, skin trauma, smoking, medications, and obesity, just to name a few.
As we mentioned above, there are seven different types of psoriasis:
  • plaque psoriasis
  • scalp psoriasis
  • nail psoriasis
  • guttate psoriasis
  • inverse psoriasis
  • pustular psoriasis
  • erythrodermic psoriasis
There’s also psoriatic arthritis, a combo of psoriasis and arthritis. Here’s what you need to know about the causes and treatments for each one.

What You Should Know About Plaque Psoriasis

This is the type you’re probably thinking of when someone mentions psoriasis. It’s characterized by clearly demarcated, raised, red, scaly patches called plaques that appear most commonly on your elbows, knees, scalp, and back (but they can pop up anywhere on the body).
Because it accounts for 80% of all cases, plaque psoriasis tends to get the most press. It’s the type addressed in most psoriasis drug commercials, and celebs including reality star Kim Kardashian and singer Cyndi Lauper have both been vocal about being plagued with plaques.

What Causes Plaque Psoriasis?

The cause for all cases of psoriasis stems from a combo of genetics, immune dysfunction, and triggers. People who have psoriasis are also more likely to have other inflammatory diseases such as Crohn’s disease, heart disease, or diabetes, suggesting some link between the underlying inflammation.
A study in Archives of Dermatology that looked at over 100,000 patients with psoriasis found those with severe psoriasis had a 46% greater chance of having diabetes than those without the skin disease.

How Do You Treat Plaque Psoriasis?

There are several treatments that target plaques. Your physician will decide which one is right for you based on your general health, any underlying conditions, and the severity of your plaque psoriasis. Your options include:
  • Topical ointments and creams such as cortisone cream, oral or injectable corticosteroids
  • Light therapy (phototherapy)
  • Systemic drugs such as Gengraf and Sandimmune (cyclosporine) and Rasuvo and Rheumatrex (methotrexate)
  • Biologic medications, which are made from living organisms and work by slowing down your overactive immune system
Research suggests that biologics for psoriasis might help with those other inflammatory diseases linked to the skin condition, too. A study in Cardiovascular Research found that treating psoriasis with biologics helps reduce the plaque build-up in the arteries, which leads to heart attacks and strokes.
However, once your skin plaques disappear, you’re not necessarily in the clear. Exposure to your triggers can bring on a new bout of plaque psoriasis. Only 10% of people are lucky enough to have what’s called “spontaneous remission,” when your skin clears up forever and you never have a flare up again.

More severe cases might require:
  • phototherapy
  • an immune suppressing oral medication
  • a biologic injection or intravenous infusion

Saturday 25 April 2020

Psoriasis and Diet: What's the Link?

From healthcentral.com

A new study says foods commonly eaten in the U.S. may play a bigger role in the skin disease than previously thought

Scientists have long known that obesity and psoriasis go hand-in-hand. Like chips and salsa or gin and tonic, if you have one disease, you’re likely to have the other. The reason is that a high BMI can lead to inflammation in the body, which increases the risk for developing the challenging skin condition known as psoriasis—or worsening existing symptoms if you already have it. Now, a new study published in the Journal of Investigative Dermatology suggests there may be another mechanism at work: Fat cells themselves may not be the culprits, say researchers, but rather specific types of foods are to blame.

In the study, conducted at the University of California, two groups of mice were fed different diets. Once group got a typical mouse meal; the other one was given a characteristic “Western diet” (basically, the mouse equivalent of a moderate-to-high fat, processed-sugar diet that mimicked what humans would eat on the same meal plan). The mice kept it up for four weeks, after which scientists took stock of their skin, and found that the creatures who’d been chowing on the rodent version of burgers, fries, and shakes showed visible inflammatory changes including redness, scales, and thickened skin—the same hallmark symptoms consistent with human psoriasis—even if the mice hadn’t appreciably gained weight.

“This is important because many people think that it’s obesity alone that leads to the increased risk for psoriasis,” says senior study author Sam T. Hwang, M.D., Ph.D., department chair and professor of dermatology at the University of California Davis School of Medicine. “What this shows is that dietary changes can have a radical impact on the skin—so it’s not just weight that makes a difference for developing psoriasis, but the types of foods you eat.”

These so-called “Western” foods are typically high in saturated fat (butter, red meat, cheese and other dairy products made from whole milk, for example), plant-based oils (such as palm oil, coconut oil, and canola oil) and processed ingredients, like those in many baked goods. The foods also contain high levels of simple sugars, found in fruit juices, soda, candy, and even some whole fruits like apples, bananas, and watermelon.

                                                                                           iStock

    A Gut Reaction

    So, what is it about these foods, common in American diets, that causes inflammation in the first place? Researchers believe they alter the composition of the microbiome, those billions of bacteria living in your gut that help maintain general health and the health of your immune system. Changing the balance of these bacteria through diet may ultimately lead to an inflammatory response related to psoriasis.

    To break it down even further (we know, it’s complicated), “high-fat foods cause bile acids from your gall bladder and liver to go into the gut to help with digestion,” says Ronald Prussick, M.D., an assistant clinical professor of dermatology at George Washington University and medical director of the Washington Dermatology Centre. “These acids then cause bad bacteria to form, leading to inflammation inside the body.”

    What this all means: The study proposes that what you eat can alter the gut microbiome, causing changes in bile acid levels, which can affect inflammation.

    This theory was tested in the study when the researchers administered cholestyramine, a drug used to lower cholesterol (high levels of which are found in fast foods and other “western” fare), to the mice and found that it helped reduce the risk of skin inflammation. “Cholestyramine was shown to bind to bile acids in the intestine and release through the stool, allowing for inflammation to be lowered in the mice,” Dr. Hwang says.

    Food for Thought

    Doctors have long maintained that there is no single food that can treat or cure psoriasis, and that’s still true. But if you have the skin condition or are at risk for the disease (which is frequently genetically determined), limiting or eliminating foods high in saturated fats and simple sugars can lessen the chances for inflammation—and therefore possibly psoriasis, Dr. Hwang says.

    What to eat instead? A Mediterranean-type diet, characteristically rich in healthy fats and omega-3 fatty acids, is known to help fight inflammation. It includes foods such as olive oil, avocados, nuts, seeds, fish like salmon and lake trout, and some meat or dairy from grass-fed animals, as well as fresh vegetables and fruits low on the glycaemic index, like berries. “Switching to a healthier diet can increase the chances of treating psoriasis more effectively,” says Dr. Prussick.

    Additionally, Dr. Prussick suggests cooking on lower heat by stewing, poaching, boiling, and steaming foods rather than grilling, frying, or toasting them. “Heat causes sugars in foods to bind to proteins, known as advanced glycation end products (AGEs), which causes more inflammation,” he says. He also recommends cooking with acids such as vinegar or lemon juice, which can reduce AGEs by 50%.

    https://www.healthcentral.com/article/psoriasis-and-diet

    Wednesday 22 April 2020

    The 5 Best Diets for Psoriatic Arthritis

    From healthcentral.com

    No boring bites here. These diets are full of flavour, and they come with one awesome benefit—fewer psoriatic arthritis flares!

    It’s no secret that what you eat can impact your health. And if you have a chronic disease, diet plays a huge role in keeping symptoms at bay.
    “This is especially true for people who have too much inflammation in their body, which is what happens with psoriatic arthritis,” says Robin Foroutan, R.D.N., an integrative medicine dietitian and spokesperson for the Academy of Nutrition and Dietetics.

    It is estimated that about one in five patients with psoriasis will develop psoriatic arthritis, an autoimmune condition that can lead to inflammation that damages your skin and your joints.
    “Many different foods, especially foods high in antioxidants, can help the body balance inflammation, and that’s why diet is so important,” says Foroutan.

    On the flip side, “some foods are pro-inflammatory in and of themselves, meaning they trigger an inflammatory cascade,” says Foroutan. “For someone with PsA, that’s like pouring gasoline on a wildfire.”

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    Are You Pro Anti-Inflammatory Diet? According to the National Psoriasis Foundation, an anti-inflammatory diet composed of lean proteins, whole grains, and fresh produce is often recommended for those with psoriatic arthritis.

    “Many diets will claim that they are anti-inflammatory. However, certain diets score better when it comes to research and efficacy–these diets include the Mediterranean Diet, the Dash Diet, and a Vegetarian Diet,” says Angel Planells, R.D.N., Seattle-based registered dietitian nutritionist and spokesperson for the Academy of Nutrition & Dietetics. “These diets have a higher intake of health protective nutrients (fruits, vegetables, nuts, seeds, healthy fats, lean protein).”

    “On the most basic level, sugar, white refined grains, processed red meat and any food that provides minimal to no nutrient density should be avoided,” says Kristin Kirkpatrick, R.D.N., registered dietitian nutritionist and lead dietitian at Wellness Nutrition Services at Cleveland Clinic Wellness & Preventive Medicine. “What should be adhered to are colourful foods representing high phytonutrient/antioxidant levels often found in plants, such as fruits, vegetables and whole grains.”
    The good news is that studies have found there are actually a bunch of diet plans that can help you eat to beat inflammation. Here’s a rundown on five of the top picks, plus their pros and cons, and who might want to consider them.

    Mediterranean Diet

    Basics: The Mediterranean Diet consists of mostly vegetables, fruits, and whole grains, moderate amounts of dairy, fish, and meat (with minimal amount of red meat), and minimal processed foods and sugar. Healthy fats, especially extra virgin olive oil, also get a big check mark in this diet.

    Pros for PsA: The Mediterranean Diet is considered an ‘anti-inflammatory’ diet. One study found that patients with PsA who followed a Mediterranean Diet compared to those who didn’t reported lower levels of PsA disease activity.

    Cons for PsA: According to Harvard University, the Mediterranean Diet could increase your risk of excess calorie intake, as portion size isn’t emphasized, which may cause weight gain.

    You might like it if: You are looking to decrease the amount of processed foods you eat and increase the amount of produce.

    DASH Diet

    Basics: The ‘DASH’ stands for Dietary Approaches to Stop Hypertension. It was designed as a diet to lower blood pressure, and it puts major stock in vegetables, fruits, and low-fat dairy foods. Also emphasized are moderate amounts of whole grains, fish, poultry, and nuts as well as low-sodium intake.

    Pros for PsA: Like the Mediterranean Diet, the DASH Diet cuts out foods known to increase PsA symptoms, including processed foods. Since it's goal is to improve heart health, this diet is another pro for those with PsA, who are at higher risk of developing heart disease.

    Cons for PsA: This diet was specifically created to lower blood pressure, which may not be necessary for those with PsA (i.e. those who do not have hypertension).

    You might like it if: You are looking to improve your heart health (along with your PsA symptoms).

    Paleo Diet

    Basics: This diet (a.k.a. the Caveman Diet) consists of primarily lean meat, fruit, fish, nuts and seeds, and cuts out the junk food and most processed foods, which can contribute to inflammation. It eliminates potentially inflammatory foods like gluten and dairy, and it allows for lots of anti-inflammatory veggies, herbs, spices, fatty fish, and high-quality meats and fats.

    Pros for PsA: There’s a version of Paleo called the AIP diet, or auto-immune paleo diet (which is an elimination-style Paleo diet), that can also be remarkably helpful for anyone with an autoimmune condition. The AIP diet requires focus on food quality and includes trial elimination of many otherwise healthy foods like eggs, beans and legumes, which are technically anti-inflammatory.

    Cons for PSA: If people were to eat too much meat and not enough veggies (which is easy to do with this diet), the level of anti-inflammatory protection would go down.

    You might like it if: You're up for meal planning and prepping, and you want to lose or maintain your weight.

    Intermittent Fasting

    Basics: This somewhat customizable diet implements different time cycles of fasting and eating. There are many different fasting methods, including the 16/8 method where you fast for 16 hours and have an 8-hour eating window. There’s also the “Eat-Stop-Eat” method where you fast for 24 hours once or twice a week.

    Pros for PsA: There is some evidence that Intermittent Fasting (IF) can help regulate the immune system and reduce inflammation, especially when paired with anti-inflammatory foods like green leafy vegetables, fatty fish, and olive oil. One study published in the journal Nutrients found that after a month of fasting, patients with PsA reported lower inflammation markers.

    Cons for PsA: It may prevent you from attaining as many nutrients as possible if you limit the amount of time (and consequently the amount of food) you eat using IF. And simply limiting the periods when you’re eating without adjusting your diet to include anti-inflammatory foods likely won’t result in major PsA improvements.

    You might like it if: You want to practice portion control and simplify your lifestyle (since you don't have to think about when to eat, only what to eat).

    Vegetarian Diet

    Basics: This diet consists of plants, plants, and more plants. Obvi.

    Pros for PsA: “The different colours you see in plant foods are signals that the food is high in ‘phytonutrients’, a.k.a. antioxidants,” says Foroutan. “These foods help the body balance inflammation and can help modulate an overactive immune system.” In other words, when you eat foods that are high in antioxidants, like vegetables, you prevent the production of inflammatory compounds and fight destructive ‘oxidant’ molecules that attack healthy cells, leading to inflammation.

    Cons for PsA: Plant-based diets often lack foods that contain vitamin D like fatty fish, cheese, and egg yolks, which is not ideal. One study published in Arthritis Research & Therapy, found that nearly 41% of participants with psoriatic arthritis had a vitamin D deficiency.

    You might like it if: You’re trying to cut back on your meat intake (which can come with a lot of inflammation-causing saturated fats), and up your consumption of veggies.

    https://www.healthcentral.com/article/best-diets-psoriatic-arthritis

    Tuesday 21 April 2020

    What To Know About COVID-19 And Psoriasis

    From southfloridareporter.com

    At present, it is unclear how COVID-19 may affect those with psoriasis, which is an immune-mediated condition. This mean the condition occurs as a result of abnormal immune system activity. Scientists are also unsure about how it may impact the treatment of these individuals.
    Some treatments for psoriasis, which are immunosuppressive medications, may increase the risk of a COVID-19, or of severe illness due to the virus. However, the effects are still unknown.

    How does COVID-19 affect people with psoriasis?

    The details of how COVID-19 affects those with psoriasis remain unknown, but there is not yet evidence to suggest that it affects them differently than people without the condition.

    According to the National Psoriasis Foundation (NPF), if a person is not taking an immunosuppressive medication and is free from other underlying diseases, there may be “minimal additional risk” of them contracting SARS-CoV-2 relative to the rest of the population.

    However, as the virus is highly transmissible, spreads rapidly, and replicates rapidly, everyone is at risk. Even asymptomatic people can transmit the virus to others.

    The NPF note that people with severe psoriasis, such as those who are on immunosuppressive therapies or have other medical conditions, probably are at higher risk of infection.

    Is COVID-19 more dangerous for people with psoriasis?

    As psoriasis is a chronic immune-mediated condition, some people may take immunosuppressant drugs to keep their symptoms under control.
    These medications can reduce immune function, which may increase the risk of infection with SARS-CoV-2 or other infectious agents. Immunosuppressive drugs could also increase the risk of severe symptoms.

    According to the Centres for Disease Control and Prevention (CDC), conditions or medications that weaken the immune system and cause people to become immunocompromised increase the risk of severe COVID-19.

    The International Psoriasis Council (IPC) recommend that people with psoriasis who receive a COVID-19 diagnosis discuss discontinuing or postponing their use of immunosuppressant medications with their doctor.

    However, the IPC caution that doctors should carefully weigh the benefit-to-risk ratio of immunosuppressive treatments on an individual basis.

    The medical board of the NPF do not recommend that people with psoriasis stop their treatment unless they have an active infection. They suggest that those in high risk groups discuss their options with their doctor.
    The CDC list the following as high risk:
    • those aged 65 years and older
    • people living in a nursing home or care facility
    • smokers
    • individuals with underlying medical conditions (especially if poorly controlled) or risk factors that include:
      • chronic lung disease
      • moderate or severe asthma
      • serious heart conditions
      • a weakened immune system, for instance, due to cancer treatment or HIV
      • severe obesity
      • diabetes
      • chronic kidney disease
      • liver disease
    The World Health Organization (WHO) and other expert bodies are still learning about the effects of COVID-19 on those with co-occurring conditions.

    Symptoms to look out for

    The WHO list the most common COVID-19 symptoms as:
    • a dry cough
    • fatigue
    • fever
    They state that other possible symptoms include:
    • aches and pains
    • diarrhoea
    • difficulty breathing
    • nasal congestion
    • runny nose
    • shortness of breath
    • sore throat
    Some people with COVID-19 also report a loss of taste or smell.
    Symptoms typically develop within 2–14 days of exposure to the virus. They range from mild to severe, although the majority of people experience a relatively mild form of the disease, which will not require specialist treatment in a hospital.

    Some people may be asymptomatic, meaning that they have no symptoms, despite testing positive for the virus that causes COVID-19. Asymptomatic individuals can still transmit the virus to others, though.

    Extra care and precautions

    People can reduce the risk of exposure to the novel coronavirus by:
    • washing their hands regularly with soap and water for at least 20 seconds or using an alcohol-based hand sanitizer
    • maintaining a distance of 6-feet (2-meter) or more from others, especially those who are showing symptoms
    • staying home as much as possible and limiting the amount of time that they spend out in public places, including parks and grocery stores
    • stocking up on food, medications, and other essential items to reduce the number of trips outside the home
    • avoiding nonessential travel
    • cleaning and disinfecting surfaces and items in the home daily, including faucets, door handles, toilet handles, and remote controls
    • avoiding sharing cutlery, towels, and other personal items with family members
    • having sick members of the household isolate themselves as much as possible until symptoms resolve
    • wearing a cloth face covering or mask when in public outside the home
    • sick persons should wear a mask whenever in the presence of others

    Anyone who thinks that they may have become exposed to the virus should:
    • monitor their symptoms closely and check their temperature daily for fever
    • call their doctor immediately if symptoms develop
    • seek immediate medical attention if breathing difficulties or chest pain occurs
    It is advisable to call ahead before presenting at an emergency facility in case they need to put safety measures in place.

    The NPF recommend that people with psoriasis discuss their treatment with their doctor. A doctor may recommend continuing medications or taking a break from them.
    It is important that people only adjust or stop their treatment after consulting with their doctor.

    Treatment and symptom management

    So far, there is no specific treatment or vaccine for COVID-19. In those who contract the virus and develop symptoms, treatment aims to alleviate these symptoms. Treatments include:
    • cough medicines
    • hydration
    • pain relief
    • rest
    People who develop severe illness will require hospitalization. In the hospital, doctors may put them on oxygen or a ventilator, or provide other specialist care.
    In some cases, doctors may speak to a person about participating in a clinical trial, which is very important in helping experts learn about the disease and find effective treatments.

    People with psoriasis who develop COVID-19 should speak to their doctor about their psoriasis treatment while ill.
    Those taking immunosuppressive medications will often need to stop treatment temporarily until their doctor says that it is safe to resume. The doctor will advise on other types of psoriasis treatment on a case-by-case basis.

    What to do if the test is positive

    When someone tests positive for the novel coronavirus, their doctor will provide them with instructions for recovery. They will also explain to the individual how to self-isolate to reduce the spread of the virus to others.
    People with mild symptoms can typically recover at home, while those with severe illness often require a hospital stay.

    Outlook

    It is difficult to determine the outlook for people with COVID-19 and psoriasis, but this generally depends on:
    • the severity of the disease
    • the person’s age, sex, and ethnicity
    • the presence of additional underlying health conditions
    Data from China showed that 80% of people who develop COVID-19 have mild-to-moderate symptoms and recover well. Of the remainder, 13.8% develop severe disease, and 6.1% become critical and require intensive care.

    Prompt medical treatment may improve the outlook of people with severe disease and reduce the risk of complications, which include pneumonia and organ failure. In some cases, COVID-19 can also lead to death.

    Summary

    At present, experts know little about the effects of COVID-19 on people with psoriasis.
    However, it seems that those who are not taking an immunosuppressive medication and do not have another co-occurring disorder have a similar risk to the rest of the population.

    People taking immunosuppressive therapies who receive a COVID-19 diagnosis should consult their doctor immediately. It is likely that the doctor will advise them to stop taking these medications until they recover.

    There is no specific treatment for the novel coronavirus, but individuals can reduce their risk of contracting it by maintaining physical distance from others, avoiding unnecessary public outings, and practicing good hygiene.

    Individuals with psoriasis should speak to their doctor about their specific case. A doctor will address any concerns that a person has, and they may adjust their treatment plan accordingly.

    https://southfloridareporter.com/what-to-know-about-covid-19-and-psoriasis/

    Thursday 16 April 2020

    Let's Talk About the Causes of Psoriasis

    From healthcentral.com

    Psoriasis can be a pain: It's often itchy and stings like whoa. It might also make you feel self-conscious because psoriasis lesions can be prominent on your arms, legs, and face. If you have it, it might help to know that you're not alone: More than 8 million Americans are in the same boat. Still, you're probably wondering, why me? Good question. Understanding the causes and triggers can help you keep this chronic condition under control—and, hopefully, stay in the clear.

    What’s Psoriasis, Again? Let’s Recap

    Psoriasis is an inflammatory skin condition marked by red, scaly patches of skin that can appear as small bumps or thick, raised lesions. These can crop up anywhere on the body, but the most typical spots are knees and other parts of the legs, elbows, torso, and face.

    While psoriasis doesn’t discriminate by age and can appear at any time, it usually makes its debut sometime between 15 and 35 years old. And unlike some diseases that favour one gender over another, psoriasis is an equal opportunist: It strikes women and men in the same numbers.

    There are seven different types of psoriasis. When you think about the condition, you’re probably picturing plaque psoriasis, the most common type. It affects 80% of those with psoriasis. Its lesions, called plaques, are red, scaly, and clearly demarcated, with peaks that can look silvery (on lighter skin) or purple (on darker skin). The other, less common types of psoriasis are:

    Guttate: This is the second most common form, which shows up as small red tear-shaped bumps on upper arms, trunk, thighs, and scalp.
  • Inverse: This causes bright red, shiny patches in folds of skin such as your groin, underarms, under breasts, and around genitals that tends to get worse from sweating and friction.
  • Pustular: As the name implies, this type of psoriasis appears as pus-filled bumps, often on hands and feet. If it covers most of your body and comes with flu-like symptoms and an increased heart rate, it can be dangerous and needs medical attention, stat.
  • Erythrodermic: This condition presents as widespread, red skin that looks like a burn. It’s the least common of all the psoriasis types.
  • Psoriatic arthritis: This version of the disease occurs when you have both psoriasis and arthritis—achy, swollen joints and inflamed, itchy skin. Up to 30% of people with psoriasis have the joint condition, too.
  • Nail psoriasis: It looks similar to nail fungus with pitting, tenderness, yellowing, and separation of the nail bed, with gunk between your skin and nail. The majority of people with nail psoriasis have other types, too. In fact, 80% to 90% of them have plaque psoriasis.