From philly.com
(HealthDay News) -- If dry, itchy scalp psoriasis is bothering you, there are things you can do to help bring it under control.
http://www.philly.com/philly/health/topics/HealthDay711785_20160624_Health_Tip__Coping_With_Scalp_Psoriasis.html
Saturday 25 June 2016
Thursday 23 June 2016
Ixekizumab clears psoriasis in up to 80% of patients
From The Pharmaceutical Journal
Psoriasis is a chronic inflammatory disease caused by dysregulated immune responses. Recent advances in understanding the underlying cytokine networks has led to attempts to create drugs that can completely clear psoriasis plaques.
In three phase III trials, researchers explored the efficacy of ixekizumab, a monoclonal antibody against interleukin-17a, in a total of 3,866 patients with moderate to severe psoriasis.
They found that, after 12 weeks, 76.4–81.8% of patients who were randomly assigned to active treatment had minimal or clear psoriasis, compared with 3.2% of patients assigned to placebo. At week 60, 68.7–78.3% of patients who received ixekizumab had maintained their improvement.
In The New England Journal of Medicine (online, 8 June 2016), the researchers say the response rates are some of the highest ever seen from a psoriasis drug, but caution that long-term safety needs assessment.
http://www.pharmaceutical-journal.com/news-and-analysis/research-briefing/ixekizumab-clears-psoriasis-in-up-to-80-of-patients/20201293.article
Psoriasis is a chronic inflammatory disease caused by dysregulated immune responses. Recent advances in understanding the underlying cytokine networks has led to attempts to create drugs that can completely clear psoriasis plaques.
In three phase III trials, researchers explored the efficacy of ixekizumab, a monoclonal antibody against interleukin-17a, in a total of 3,866 patients with moderate to severe psoriasis.
They found that, after 12 weeks, 76.4–81.8% of patients who were randomly assigned to active treatment had minimal or clear psoriasis, compared with 3.2% of patients assigned to placebo. At week 60, 68.7–78.3% of patients who received ixekizumab had maintained their improvement.
In The New England Journal of Medicine (online, 8 June 2016), the researchers say the response rates are some of the highest ever seen from a psoriasis drug, but caution that long-term safety needs assessment.
http://www.pharmaceutical-journal.com/news-and-analysis/research-briefing/ixekizumab-clears-psoriasis-in-up-to-80-of-patients/20201293.article
Wednesday 22 June 2016
Severe psoriasis can be completely cleared with a new drug: Studies
By: Bel Marra Health
Psoriasis, a relatively common skin condition that causes patches of thick, red skin with silvery scales, can be found on various parts of the body. For many people it can be mild, but others experience severe psoriasis, which can cause a great deal of stress and self-confidence problems. Now, three large clinical trials seem to suggest a new drug can completely clear up severe psoriasis, offering hope to those who have been battling the skin condition.
Imagine for a moment what it would be like to live with pain, swelling, heat, and redness on your face, legs, lower back, palms, or the soles of your feet. This is where psoriasis can show up. For some people, the thick, red spots can even appear on genitals and inside the mouth. Now, consider after years of living with such a condition, there is hope thanks to an effective new treatment.
Three large, long-term clinical trials, led by Northwestern Medicine Investigator and professor of dermatology Kenneth Gordon, indicated that 80 percent of people with moderate to severe psoriasis experienced a complete or almost complete recovery from the skin condition with a new drug called ixekizumab. Gordon has reported that the results show “the great majority of responses persist at least 60 weeks”.
It is bad enough that psoriasis is itchy, uncomfortable, and unsightly, but experts say it is also linked to an increased risk of depression, heart disease, and diabetes. Finding effective treatment is important not only for comfort level, but overall good health.
According to those who worked on the clinical trials, the drug ixekizumab neutralizes a pathway in the immune system that promotes psoriasis.
To test the drug, clinicians enrolled close to 4,000 adult patients at more than 100 study sites in 21 countries. Everyone who took part had either moderate or severe psoriasis. Patients received either injections of ixekizumab at various doses or a placebo over a period of more than one year.
The team then assessed whether the ixekizumab reduced the severity of the skin condition compared to the placebo, and also monitored any adverse effects. By about 12 weeks, close to 82 percent of those with psoriasis had their skin condition updated to “minimal” or “clear”. By week 60, between 69 and 78 percent had maintained their improvement.
Just a few years ago, doctors thought complete clearance of this inflammatory disease was impossible. Now they see that based on the trials, they can anticipate 80 percent will have a good response to ixekizumab and about 40 percent will be completely cleared of psoriasis.
Since the results of the clinical trials were announced, the Food and Drug Administration (FDA) has approved ixekizumab.
http://www.belmarrahealth.com/severe-psoriasis-can-be-completely-cleared-with-a-new-drug-studies/
Psoriasis, a relatively common skin condition that causes patches of thick, red skin with silvery scales, can be found on various parts of the body. For many people it can be mild, but others experience severe psoriasis, which can cause a great deal of stress and self-confidence problems. Now, three large clinical trials seem to suggest a new drug can completely clear up severe psoriasis, offering hope to those who have been battling the skin condition.
Imagine for a moment what it would be like to live with pain, swelling, heat, and redness on your face, legs, lower back, palms, or the soles of your feet. This is where psoriasis can show up. For some people, the thick, red spots can even appear on genitals and inside the mouth. Now, consider after years of living with such a condition, there is hope thanks to an effective new treatment.
Three large, long-term clinical trials, led by Northwestern Medicine Investigator and professor of dermatology Kenneth Gordon, indicated that 80 percent of people with moderate to severe psoriasis experienced a complete or almost complete recovery from the skin condition with a new drug called ixekizumab. Gordon has reported that the results show “the great majority of responses persist at least 60 weeks”.
It is bad enough that psoriasis is itchy, uncomfortable, and unsightly, but experts say it is also linked to an increased risk of depression, heart disease, and diabetes. Finding effective treatment is important not only for comfort level, but overall good health.
According to those who worked on the clinical trials, the drug ixekizumab neutralizes a pathway in the immune system that promotes psoriasis.
To test the drug, clinicians enrolled close to 4,000 adult patients at more than 100 study sites in 21 countries. Everyone who took part had either moderate or severe psoriasis. Patients received either injections of ixekizumab at various doses or a placebo over a period of more than one year.
The team then assessed whether the ixekizumab reduced the severity of the skin condition compared to the placebo, and also monitored any adverse effects. By about 12 weeks, close to 82 percent of those with psoriasis had their skin condition updated to “minimal” or “clear”. By week 60, between 69 and 78 percent had maintained their improvement.
Just a few years ago, doctors thought complete clearance of this inflammatory disease was impossible. Now they see that based on the trials, they can anticipate 80 percent will have a good response to ixekizumab and about 40 percent will be completely cleared of psoriasis.
Since the results of the clinical trials were announced, the Food and Drug Administration (FDA) has approved ixekizumab.
http://www.belmarrahealth.com/severe-psoriasis-can-be-completely-cleared-with-a-new-drug-studies/
Wednesday 15 June 2016
Do YOU have flaking, sore and dry skin? Five tips to beat THIS chronic condition
By Olivia Lerche
These patches normally appear on elbows, knees, scalp and lower back, but can appear anywhere on the body. Most people are only affected with small patches but the skin can become itchy or sore.
NHS Choices said psoriasis affects around 2 per cent of people in the UK. It can start at any age, but most often develops in adults under 35 years old.
The condition occurs due to an over-reaction of the immune system, which causes inflammation and rapid growth of skin cells.
Skin cells are normally made and replaced every three to four weeks, but in psoriasis this process only lasts about three to seven days. The resulting build-up of skin cells is what creates the patches associated with psoriasis.
Experts have recommended five way to beat the painful skin condition.
Essential vitamins
Vitamin D, which people can get from the sun, is it vital for bone health as well as obesity and diabetes, but it can also help with psoriasis.
“Vitamin D can change the way cells grow,” said Shona Wilkinson, Nutritionist at SuperfoodUK.com.
“As those who suffer from Psoriasis tend to produce more skin cells, it can slow this process down and cause the plaques to become less scaly and thinner.
“It can be difficult to get enough sunlight to stimulate vitamin D synthesis in this country – even in the summer.
“The ideal first step is to get your vitamin D level tested to see how much yours needs to increase, if at all. In most cases, your doctor will do this for you. If you’re deficient (under 75 nmol/L) or ‘insufficient’ (under 100 nmol/L) then taking a supplement can be the best way to get the level up.”
Cassandra Barns, nutritionist said: “Try new Once A Day Sunshine D from Quest Vitamins, a high-strength vitamin D chewable tablet.”
Fish
Psoriasis is an autoimmune condition that causes inflammation and Omega 3 fatty acids, found in fish oil can be very helpful in reducing it - according to experts.
However, not all fatty acids are the same - Omega 6, which is present in vegetable oils - might actually increase inflammation.
“Unfortunately, many people have much higher levels of omega 6 than omega 3 in their body, often due to the use of vegetable oils in cooking and the lack of oily fish consumption,” said Dr Marilyn Glenville, nutritionist and author of Natural Alternatives of Sugar.
“To correct this balance, cut out all vegetable oils and margarines (as well as processed food) and replace it with healthy fats such as olive oil, coconut oil, butter or ghee.
“Aim to eat oily fish such as sardines, salmon or mackerel at least three times a week. For additional support, it may be helpful to take a good quality omega-3 fish oil supplement such as NHP’s Omega 3 Support.”
Keep the skin moist
To relieve skin from itchiness and discomfort, expert advise sufferers to keep the skin moist and nourished from the outside.
However, experts warn some emollient creams that are sometimes recommended by doctors and pharmacists, rarely provide long-term relief.
Cassandra Barns said: “They can even irritate already inflamed skin, as very often they contain chemicals, such as chlorocresol and cetearyl alcohol.
“Instead, try natural products, such as Hydrating Facial Serum from What Skin Needs which contains a blend of natural ingredients including Plantolin, an extract from an Australian indigenous plant.
“This powerful ingredient along natural essential oils can help to manage skin conditions by reducing inflammation and oxidative damage. The formula as a whole is designed to reduce irritation, soothe and repair dry and damaged skin.”
Go natural, Avoid junk food
Junk food can cause psoriasis to flare up, according to experts.
“Junk foods very often come with ingredients that may aggravate skin problems and worsen inflammation – including additives, sugar and excess salt,” added Cassandra.
“They are also usually high in quickly digested and absorbed carbohydrates, think white bread, pastries and crisps, which can upset the balance of natural flora in our gut as well as blood sugar and hormone balance, all of which can tie in with skin problems.
Stress
Stress can not only make Psoriasis worse but Psoriasis can make people stressed - argue experts.
Dr Glenville said people can improve their mood by making sure levels of serotonin stay high.
“A simple change of diet can work wonders,” she said.
“The body makes serotonin from tryptophan, which occurs naturally in foods such as dairy products, fish, bananas, dried dates, soya, almonds and peanuts. The manufacture of serotonin depends on how much tryptophan is transported into your brain.
“Combining the foods mentioned above with unrefined carbohydrates, such as brown rice, wholemeal bread or oats, helps the body to release insulin to help tryptophan uptake to the brain. A good example would be to kick start your day with eggs and wholemeal toast for breakfast.”
http://www.express.co.uk/life-style/health/679750/Flaking-sore-dry-skin-psoriasis-five-tips-to-beat-chronic-skin-condition
These patches normally appear on elbows, knees, scalp and lower back, but can appear anywhere on the body. Most people are only affected with small patches but the skin can become itchy or sore.
NHS Choices said psoriasis affects around 2 per cent of people in the UK. It can start at any age, but most often develops in adults under 35 years old.
The condition occurs due to an over-reaction of the immune system, which causes inflammation and rapid growth of skin cells.
Skin cells are normally made and replaced every three to four weeks, but in psoriasis this process only lasts about three to seven days. The resulting build-up of skin cells is what creates the patches associated with psoriasis.
Experts have recommended five way to beat the painful skin condition.
Essential vitamins
Vitamin D, which people can get from the sun, is it vital for bone health as well as obesity and diabetes, but it can also help with psoriasis.
“Vitamin D can change the way cells grow,” said Shona Wilkinson, Nutritionist at SuperfoodUK.com.
“As those who suffer from Psoriasis tend to produce more skin cells, it can slow this process down and cause the plaques to become less scaly and thinner.
“It can be difficult to get enough sunlight to stimulate vitamin D synthesis in this country – even in the summer.
“The ideal first step is to get your vitamin D level tested to see how much yours needs to increase, if at all. In most cases, your doctor will do this for you. If you’re deficient (under 75 nmol/L) or ‘insufficient’ (under 100 nmol/L) then taking a supplement can be the best way to get the level up.”
Cassandra Barns, nutritionist said: “Try new Once A Day Sunshine D from Quest Vitamins, a high-strength vitamin D chewable tablet.”
Fish
Psoriasis is an autoimmune condition that causes inflammation and Omega 3 fatty acids, found in fish oil can be very helpful in reducing it - according to experts.
However, not all fatty acids are the same - Omega 6, which is present in vegetable oils - might actually increase inflammation.
“Unfortunately, many people have much higher levels of omega 6 than omega 3 in their body, often due to the use of vegetable oils in cooking and the lack of oily fish consumption,” said Dr Marilyn Glenville, nutritionist and author of Natural Alternatives of Sugar.
“To correct this balance, cut out all vegetable oils and margarines (as well as processed food) and replace it with healthy fats such as olive oil, coconut oil, butter or ghee.
“Aim to eat oily fish such as sardines, salmon or mackerel at least three times a week. For additional support, it may be helpful to take a good quality omega-3 fish oil supplement such as NHP’s Omega 3 Support.”
Keep the skin moist
To relieve skin from itchiness and discomfort, expert advise sufferers to keep the skin moist and nourished from the outside.
However, experts warn some emollient creams that are sometimes recommended by doctors and pharmacists, rarely provide long-term relief.
Cassandra Barns said: “They can even irritate already inflamed skin, as very often they contain chemicals, such as chlorocresol and cetearyl alcohol.
“Instead, try natural products, such as Hydrating Facial Serum from What Skin Needs which contains a blend of natural ingredients including Plantolin, an extract from an Australian indigenous plant.
“This powerful ingredient along natural essential oils can help to manage skin conditions by reducing inflammation and oxidative damage. The formula as a whole is designed to reduce irritation, soothe and repair dry and damaged skin.”
Go natural, Avoid junk food
Junk food can cause psoriasis to flare up, according to experts.
“Junk foods very often come with ingredients that may aggravate skin problems and worsen inflammation – including additives, sugar and excess salt,” added Cassandra.
“They are also usually high in quickly digested and absorbed carbohydrates, think white bread, pastries and crisps, which can upset the balance of natural flora in our gut as well as blood sugar and hormone balance, all of which can tie in with skin problems.
Stress
Stress can not only make Psoriasis worse but Psoriasis can make people stressed - argue experts.
Dr Glenville said people can improve their mood by making sure levels of serotonin stay high.
“A simple change of diet can work wonders,” she said.
“The body makes serotonin from tryptophan, which occurs naturally in foods such as dairy products, fish, bananas, dried dates, soya, almonds and peanuts. The manufacture of serotonin depends on how much tryptophan is transported into your brain.
“Combining the foods mentioned above with unrefined carbohydrates, such as brown rice, wholemeal bread or oats, helps the body to release insulin to help tryptophan uptake to the brain. A good example would be to kick start your day with eggs and wholemeal toast for breakfast.”
http://www.express.co.uk/life-style/health/679750/Flaking-sore-dry-skin-psoriasis-five-tips-to-beat-chronic-skin-condition
Monday 13 June 2016
Cure Your Bad Psoriasis Today!
By Michelle Lehan
Changing what you eat can have all the effect on the planet, particularly on the off chance that you have psoriasis. The body is loaded with poisons from the air we inhale to the nourishment we eat. The most ideal approach to expel these poisons is through the pee and not through the skin; this is particularly imperative for sufferers of psoriasis.
In the event that you are determined to have psoriasis, it is best to change your dietary patterns as quickly as time permits to reduce the side effects. Eating entire sustenance rather than handled nourishment is a decent beginning. You need to keep the poisons in the framework to a base and this should be possible by eating natural produce rather than produce developed utilizing pesticides. On the off chance that natural sustenance is out of your range, make a point to, at any rate to wash off leafy foods well to expel every one of the chemicals.
Crude is the most ideal approach to devour vegetables since they lose a few supplements when cooked. Crude vegetables are higher in fiber and are simple for the digestive framework to handle. Easy foods that provide nourishment that are simple for the digestive framework to process are beans, fish, nuts, green, verdant vegetables, and crisp organic product. The more leafy foods that are in your eating regimen the more outlandish you are to create hypersensitivity.
Fats are regularly not extraordinary for your body, but rather the body needs a little measure of unsaturated fats to legitimately work. Unsaturated fats have impact in disposing of and diminishing aggravation. A portion of the best unsaturated fats you can add to the eating routine are cool water fish, flax seed, and green verdant vegetables.
High sodium nourishment is bad for you and it can leave you dehydrated. Not all salt is made equivalent. Changing out your refined salt with ocean salt is more normal, sound decision. Common ocean salt will raise your vitality, calm the manifestations of hypersensitivity and rashes, secure against radiation, adjust the corrosive in the body, give you essential minerals, add imperiousness to contamination, and supplant lost electrolytes.
It's really all pretty simple,By just changing what you eat, the body can take steps to normally recuperate itself and stay healthy. So give it a try, you have nothing to lose regain your confidence and take the leap to healthier living!
http://ezinearticles.com/?Cure-Your-Bad-Psoriasis-Today!&id=9435004
Changing what you eat can have all the effect on the planet, particularly on the off chance that you have psoriasis. The body is loaded with poisons from the air we inhale to the nourishment we eat. The most ideal approach to expel these poisons is through the pee and not through the skin; this is particularly imperative for sufferers of psoriasis.
In the event that you are determined to have psoriasis, it is best to change your dietary patterns as quickly as time permits to reduce the side effects. Eating entire sustenance rather than handled nourishment is a decent beginning. You need to keep the poisons in the framework to a base and this should be possible by eating natural produce rather than produce developed utilizing pesticides. On the off chance that natural sustenance is out of your range, make a point to, at any rate to wash off leafy foods well to expel every one of the chemicals.
Crude is the most ideal approach to devour vegetables since they lose a few supplements when cooked. Crude vegetables are higher in fiber and are simple for the digestive framework to handle. Easy foods that provide nourishment that are simple for the digestive framework to process are beans, fish, nuts, green, verdant vegetables, and crisp organic product. The more leafy foods that are in your eating regimen the more outlandish you are to create hypersensitivity.
Fats are regularly not extraordinary for your body, but rather the body needs a little measure of unsaturated fats to legitimately work. Unsaturated fats have impact in disposing of and diminishing aggravation. A portion of the best unsaturated fats you can add to the eating routine are cool water fish, flax seed, and green verdant vegetables.
High sodium nourishment is bad for you and it can leave you dehydrated. Not all salt is made equivalent. Changing out your refined salt with ocean salt is more normal, sound decision. Common ocean salt will raise your vitality, calm the manifestations of hypersensitivity and rashes, secure against radiation, adjust the corrosive in the body, give you essential minerals, add imperiousness to contamination, and supplant lost electrolytes.
It's really all pretty simple,By just changing what you eat, the body can take steps to normally recuperate itself and stay healthy. So give it a try, you have nothing to lose regain your confidence and take the leap to healthier living!
http://ezinearticles.com/?Cure-Your-Bad-Psoriasis-Today!&id=9435004
Tuesday 7 June 2016
5 Perfect Anti-Dandruff Solutions To Leave Your Scalp Dandruff-Free
By Ravi Patel
Dandruff is a common problem for many years now. Factors like over exposure to pollution, dry scalp and stress make you more vulnerable to dandruff issues. Besides truly upsetting you, dandruff causes further damage to the overall health of your hair and scalp. Want to get rid of those pesky white flakes?
Here we have brought to you five effective drugstore products that will help reduce that white flakes called dandruff. Upon regular use for several months, you can get dandruff-free hair. Let's check out them quickly.
Head & Shoulders Classic Clean Dandruff Shampoo
The deep cleaning formula in Head & Shoulders Classic shampoo helps reduce dryness and itching in scalp, which eventually loosens dandruff flakes and clear them of your scalp. With regular use of the shampoo, you will see healthy scalp and nourished hair with no presence of white flakes.
Dandruff is a common problem for many years now. Factors like over exposure to pollution, dry scalp and stress make you more vulnerable to dandruff issues. Besides truly upsetting you, dandruff causes further damage to the overall health of your hair and scalp. Want to get rid of those pesky white flakes?
Here we have brought to you five effective drugstore products that will help reduce that white flakes called dandruff. Upon regular use for several months, you can get dandruff-free hair. Let's check out them quickly.
Head & Shoulders Classic Clean Dandruff Shampoo
The deep cleaning formula in Head & Shoulders Classic shampoo helps reduce dryness and itching in scalp, which eventually loosens dandruff flakes and clear them of your scalp. With regular use of the shampoo, you will see healthy scalp and nourished hair with no presence of white flakes.
Wednesday 1 June 2016
Psoriasis and smoking: Links and risks published by Dove Medical Press
Psoriasis: Targets and Therapy has published the review "Psoriasis and smoking: links and risks".
As corresponding author Professor Luigi Naldi says "The review in Psoriasis: Targets and Therapy throws new light on the relation between smoking habits and psoriasis. Smoking influences the onset and the severity of psoriasis, and negatively influences the response to systemic treatment. Several pathomechanisms are involved including oxidative stress, interaction with signalling pathways and vascular influences. Dermatologists could play a major role in reducing the health burden of smoking by influencing their patients changing behavior."
As Dr Uwe Wollina, Editor-in-Chief, explains "This paper demonstrates important links between smoking and worsening of psoriasis or reduced therapeutic response of the disease. It points to the fact that patients who are a smoker and are affected by psoriasis can positively influence the course of their disease by quitting smoking."
Dove Medical Press Ltd is a privately held company specializing in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine.
http://www.eurekalert.org/pub_releases/2016-05/dmp-pas053016.php
As corresponding author Professor Luigi Naldi says "The review in Psoriasis: Targets and Therapy throws new light on the relation between smoking habits and psoriasis. Smoking influences the onset and the severity of psoriasis, and negatively influences the response to systemic treatment. Several pathomechanisms are involved including oxidative stress, interaction with signalling pathways and vascular influences. Dermatologists could play a major role in reducing the health burden of smoking by influencing their patients changing behavior."
As Dr Uwe Wollina, Editor-in-Chief, explains "This paper demonstrates important links between smoking and worsening of psoriasis or reduced therapeutic response of the disease. It points to the fact that patients who are a smoker and are affected by psoriasis can positively influence the course of their disease by quitting smoking."
###
Psoriasis: Targets and Therapy is an international, peer-reviewed, open access journal focusing on psoriasis, nail psoriasis, psoriatic arthritis and related conditions, identification of therapeutic targets and the optimal use of integrated treatment interventions to achieve improved outcomes and quality of life.Dove Medical Press Ltd is a privately held company specializing in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine.
http://www.eurekalert.org/pub_releases/2016-05/dmp-pas053016.php
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