Friday, 30 October 2020

World Psoriasis Day 2020: Dermatologist explains why this autoimmune disease is often misdiagnosed and left untreated

From firstpost.com

Psoriasis primarily affects the skin, but can also cause inflammation in the internal organs, especially in the cardiovascular system, and lead to the metabolic syndrome, which includes a range of associated diseases

World Psoriasis Day 2020: Dermatologist explains why this autoimmune disease is often misdiagnosed and left untreated

    Psoriasis is a skin disease, a chronic disease and an autoimmune disease. Given how complex this disease is and the fact that it has a high prevalence and tends to go undiagnosed or misdiagnosed to a large extent, awareness about it is vital. World Psoriasis Day, observed on 29 October, is when awareness campaigns are amplified globally to fight this disease. Keeping up with this target, the theme of World Psoriasis Day 2020 is “Informed”.

    Dr Monica Bambroo, Head of Dermatology and Cosmetology, Artemis Hospitals, Gurugram, shed light on why this disease needs more spotlight than it gets, especially within the Indian healthcare system.

    Not just skin deep

    Characterised by scaly patches on the skin that grow and shed very fast, psoriasis is not just any skin disease. “The common man assumes that skin diseases are either fungal or bacterial in nature but that’s not the case with psoriasis,” says Dr Bambroo. “Psoriasis is a systemic disease, which is why it’s classified as an autoimmune disease. Your immune system is supposed to protect you, keep you safe. But sometimes, the immune system mistakenly attacks the body itself. In the case of psoriasis, the immune system attacks the largest organ - the skin - causing inflammation and all the associated symptoms.”

    “Normally, skin diseases affect only the skin,” she adds. “But if you have psoriasis, the inflammation can occur in your internal organs as well, especially in the cardiovascular system. Psoriasis can even cause metabolic syndrome, which includes a range of associated diseases.”

    Diagnosis, misdiagnosis and delay in diagnosis

    Dr Bambroo explains that since psoriasis symptoms may resemble those of other diseases, especially other skin diseases, it may not be easy to diagnose until you visit a specialist. “Early diagnosis and appropriate treatment are essential if you have psoriasis,” she adds. “We often observe that if psoriasis patients are unable to diagnose or control their disease then they tend to develop obesity, diabetes and cardiovascular diseases in the long run.”

    “Another important aspect is psoriatic arthritis,” she adds. “Although it’s difficult to predict who will develop psoriatic arthritis eventually, care must be taken early on by all psoriasis patients to prevent it. Mostly, patients come to us after eight to nine years and they have symptoms like joint pain, inflammation and swelling in the small joints of the hands and deformities in finger joints. These are the long-term implications of psoriasis that need to be prevented.”

    Another long-term implication of psoriasis is related to mental health. “Patients usually get distressed, have depressive symptoms and may not feel accepted by society,” Dr Bambroo says, indicating that since people associate being social with being presentable - and psoriasis may threaten their presentability - patients often feel isolated and lonely. “These factors increase their risks of developing mental health issues in comparison to others around them,” she adds. “The biggest problem with psoriasis is the fact that it affects your confidence deeply.”

    Taking psoriasis seriously

    “Diagnosing psoriasis doesn’t take too much effort or investigation but people tend to take skin diseases more lightly than they should,” Dr Bambroo comments. “Most people may assume it’s just a small rash, it will go away by itself and won’t affect my health much. People are also unaware of their family medical history, and since genetics play a role in causing psoriasis, this may also lead to delayed diagnosis or misdiagnosis.”

    “But since predicting what health problems psoriasis may cause later is difficult, it’s important that you take this disease seriously. For example, if a young patient has psoriasis and we ignore it, it can have a lifelong and incapacitating impact,” she says. “This is the reason why early and correct treatment is vital in the case of psoriasis.”

    How to prevent flare-ups

    Dr Bambroo mentions that while you can’t control the genetic causes of psoriasis, you can manage the environmental factors that can trigger flare-ups. “Smoking and alcohol consumption tend to cause more flare-ups and so do obesity and lack of weight management. Taking care of these factors and looking after the health of your skin as winter season approaches can help psoriasis patients manage their flare-ups better. Stress also causes psoriasis flare-ups and we have especially seen many such cases during the COVID-19 pandemic. You have to keep yourself stress-free by meditating, doing yoga and following a daily routine,” she adds.

    Although psoriasis is not curable and is a chronic disease, there are many treatment options available now including corticosteroids, vitamin D derivative creams, immunosuppressants, etc. “It’s important, however, that doctors discuss viable options with the patients and customize their treatment to ensure they can actually adopt the necessary course,” Dr Bambroo says. “Going back to your doctor for follow-ups is also vital because not all medications are effective for psoriasis year after year. Plus, medications can also have side effects, so going back to your doctor for regular check-ups is necessary.”

    “The biggest limitation in psoriasis treatment I’ve found is that the best treatments are also very expensive and not covered by insurance. I think it’s very important to include diseases like psoriasis in insurance plans and reimbursements,” she adds. “Psoriasis is not a cosmetic disease that’ll disappear like pimples do. This disease has a major impact on life and affects the dermatological life quality index (DLQI) of the patient.”

    https://www.firstpost.com/health/world-psoriasis-day-2020-dermatologist-explains-why-this-autoimmune-disease-is-often-misdiagnosed-and-left-untreated-8962351.html

    Tuesday, 27 October 2020

    Psoriasis: Why early diagnosis and medication is important

    From thehealthsite.com

    Timely diagnosis and proper treatment of psoriasis are very important to treat this skin disease. Read to know more about it

    Seeking timely diagnosis and treatment of psoriasis, while recognizing the symptoms, is very important to treat this skin disease

    Psoriasis: What Triggers Flare-Ups?

    From sg.news.yahoo.com

    Psoriasis: A chronic skin condition characterised by thick red patches with flaky silvery scales

    In Singapore, an estimated 40,000 people suffer from the disease, according to the Psoriasis Association of Singapore. Psoriasis can affect men, women and children at any age, though it has been found to be more common between the ages of 15 to 45.

    Psoriasis can be mistaken for dandruff when occurring on the scalp. Besides the scalp, psoriasis can affect any part of the skin, in particular the knees, elbows, hands, feet and lower back. In severe cases, the patches can be accompanied by painful joint swelling as well as joint disfigurement.

    “Psoriasis patches can range from minor dandruff-like scaling to major eruptions covering large areas of skin,” says Associate Professor Pang Shiu Ming​, Senior Consultant from the Department of Dermatology at Singapore General Hospital (SGH), a member of the SingHealth​ group.

    “In its severe form, psoriasis can be incapacitating, significantly affecting the patient’s quality of life. On rare occasions, very severe psoriasis can be life-threatening.”

    Psoriasis symptoms

    Most psoriasis patients have mild to moderate symptoms which are likely to wax and wane, appearing and disappearing in cycles. Psoriasis symptoms may flare up for a few weeks or months and then disappear for some time, even going into remission for some years. However, in most cases, the psoriasis symptoms do eventually recur.

    A small number of patients suffer from the severe and persistent form of the skin disease.

    Mild and moderate psoriasis symptoms include:

    • Dry cracked skin prone to bleeding
    • Burning, itchy skin
    • Raised red patches with silvery scales (called plaque)

    Severe psoriasis symptoms include:

    • Inflamed and itchy patches covering large areas of skin
    • Stiff, swollen and painful joints
    • Disfigured joints, commonly fingers and toes
    • Thickened, discoloured nails which may separate from the nail beds

    Types of psoriasis

    The most common type of psoriasis is plaque psoriasis, in which patches can occur anywhere on the body. Other common types include nail psoriasis and scalp psoriasis.

    Less common types include guttate psoriasis; localised pustular psoriasis; acropustulosis, palmoplantar pustulosis, palmoplantar psoriasis; and inverse or flexural psoriasis. Erythrodermic psoriasis and generalised pustular psoriasis (Von Zumbusch) are life-threatening forms of psoriasis.

    In psoriatic arthritis, the joints become painful and swollen.

    Causes and triggers of psoriasis

    Psoriasis is believed to be caused by a combination of genetic and environmental factors which affect the body’s immune system, causing its T-cells to attack healthy skin cells.

    “A family history of psoriasis puts you at greater risk of getting the disease,” says Assoc Prof Pang.

    The disease occurs when skin cells multiply rapidly, replacing old skin cells over 3-4 days instead of the normal 3-4 weeks. This rapid multiplication causes the cells to build up on the surface of the skin, forming thick patches.

    While the exact cause of psoriasis is unknown, the following factors have been found to be triggers for the disease:

    • Skin or nail injury
    • Stress and anxiety
    • Infections such as a streptococcal (bacterial) throat infection
    • Certain medications such as antimalarial drugs or lithium
    • Exposure to cold
    • Overweight and obesity
    • Excessive alcohol consumption​
    • Smoking

    “Smoking is a risk factor for psoriasis and has also been found to increase the severity of symptoms,” adds Assoc Prof Pang.

    https://sg.news.yahoo.com/psoriasis-triggers-flare-ups-090705559.html

    Sunday, 25 October 2020

    Why early diagnosis, treatment of psoriasis is helpful

    From timesnownews.com

    Although psoriasis has no absolute cure, advanced treatment options like biologics have proven to be a revolutionizing therapy for many people living with this condition

    New Delhi: Seeking timely diagnosis and treatment of psoriasis, while recognizing the symptoms, is advisable, says a renowned dermatologist ahead of the World Psoriasis Day marked on October 29.

    According to many dermatologists, people living with moderate to severe psoriasis require access to high quality treatment and regular screening of their condition. The flare-ups on the scalp, genital and palmoplantar (that affect palms and soles) may go under diagnosed by a general physician. Hence, it is important to only consult a dermatologist for correct treatment before the symptoms grow to an even more severe stage.

    Contrary to the most prevalent perception of being as a mere 'skin disease', psoriasis is rather a chronic and an autoimmune condition which causes itchy, flaky, red patches with silvery scales on the skin and is often

    Mistaken for being contagious

    It may resemble an ordinary rash. However, psoriasis occurs when the body's immune system attacks its own healthy cells. This causes an increase in new skin cells resulting in dry patches as skin cells build up on the skin's surface.

    Dr Brijes Nair, Consultant Dermatologist, Military Hospital, Jaipur said, "Out of various dermatological conditions, I diagnose around 20 new psoriasis patients every month. After the diagnosis of patients' current stage, they are advised with a treatment option that varies as per their disease activity. Topical treatment can be prescribed for mild psoriasis without arthritis. Whereas, effective therapies like DMARDs and biologicals can be prescribed for patients suffering from mild, moderate to severe psoriasis on sensitive areas like palms, face, genitals, etc. which have the potential to affect their quality of life adversely. Immediate attention from a rheumatologist is required in case the treating dermatologists detects joint pain, inflammation in tendons and fingers, axial pain etc."

    Although psoriasis has no absolute cure, advanced treatment options like biologics have proven to be a revolutionizing therapy for many people living with this condition. Also, this may also decrease the risk of developing co-morbid conditions. Dermatologists have observed that once patients start getting positive results, they tend to discontinue their ongoing treatment. However, it is significant to note that discontinuation of the treatment can increase the chances of developing critical co-morbidities including psoriatic arthritis, cardiovascular diseases, uveitis etc. Approximately one in four people with psoriasis have psoriatic arthritis.

    After the Covid-19 outbreak it was presumed that people with auto-immune condition like psoriasis would be more prone to contracting Covid-19. This raised several questions about treatment implications and limited access to the dermatologist even forced few patients to halt their ongoing treatment. However, a recent research has found that discontinuation of the treatment can worsen a patient's existing condition and makes it difficult to manage the symptoms as they reach an advanced stage of severity.

    "During the ongoing pandemic, we encourage people with psoriasis to stay in regular contact with their dermatologist and not discontinue their treatment regimen without the intervention of their treating dermatologist. As per the current recommendations, non-infected patients can continue their ongoing treatment and only Covid positive patients need to halt any systematic and biological medications as per dermatologist's advice," added Dr Nair.

    Although virtual channels can be utilized to address routine problems, people should not dismiss the need to visit the clinics when required after following proper precautions like hand hygiene, social distancing norms, etc.

    If not managed properly in a timely manner, psoriasis may have severe physical and emotional impact on the patient's overall health. Yet, the lack of awareness about this condition often leads to a long-term delay in diagnosis and treatment. While living with many misconceptions may negatively impact a patient's quality of life, however, being rightly educated about psoriasis management plays a huge role in the recovery process. Sometimes patients fall prey to false information and even rely on only home remedies, mostly suggested by friends and family, in the hope of getting quick relief from the psoriasis symptoms. This largely contributes to the prolonged diagnosis, and may also increase the risk of developing coronary artery disease, hypertension, diabetes, etc.

    For people with psoriasis, seeking support and treatment is essential to a healthier lifestyle both physically and mentally. Therefore, an increased awareness will help psoriasis patients to recognize their symptoms subsequently resulting in timely diagnosis and treatment. Small but effective steps can facilitate the creation of an empathetic and supportive ecosystem for people living with psoriasis.

    https://www.timesnownews.com/health/article/why-early-diagnosis-treatment-of-psoriasis-is-helpful/672362

    Thursday, 22 October 2020

    Psoriasis: Brush, floss your way to better skin?

    From wfmz.com

    COLUMBUS, Ohio - For years, Douglas Levin struggled with psoriatic arthritis. Eventually, he adopted a healthier lifestyle to help counter the inflammation caused by his disease.

    "Anytime you can control it by moderating your intake of food or other things, you're that much better off," shared Levin.

    Researchers know that a problem with the immune system can trigger psoriasis. Now, Dr. Benjamin Kaffenberger, a medical dermatologist at The Ohio State University, is studying a potential link between poor oral health, bacterial infections in the mouth, and psoriasis.

    "When your body is attempting to fight this bacteria, probably it develops a little bit of a cross-reaction with the skin at the same time," Kaffenberger explained.

    Researchers surveyed 100 patients with psoriasis and 165 without psoriasis about their lifestyle and diet. The results showed that poor dental and oral health, especially gum pain, was associated with psoriasis.

    "Unfortunately, a lot of patients don't have good access to dental care, or maybe just are too busy at a certain time frame, so they may not be getting that message when they have this disease in the first place," Kaffenberger said.

    Patients who had higher fruit consumption reported less significant psoriasis. Researchers said that indicates fresh foods may be a protective factor. For Levin, lifestyle changes means psoriasis no longer controls his life or his time outdoors with his good boy.

    The Ohio State University study also reinforced earlier studies that found family history of psoriasis, smoking and obesity could be predictors of the condition.

    https://www.wfmz.com/health/health-beat/health-beat-psoriasis-brush-floss-your-way-to-better-skin/article_2e1944f4-13de-11eb-8252-0fe34910eebd.html

    Sunday, 18 October 2020

    The 4 Best Shampoos For Psoriasis

    From elitedaily.com

    Dealing with psoriasis can be difficult and stressful — but there are ways to manage this autoimmune condition on your own. For example, if you have psoriasis on your scalp, using the right shampoo can make a big difference. According to board-certified hair loss expert Dr. William Yates, with whom Elite Daily spoke for this article, the best shampoos for psoriasis contain salicylic acid or coal tar, so look for products that contain one of those ingredients. Salicylic acid can soften and break down thick patches of psoriasis, while coal tar is useful for people experiencing scalp irritation and itching. Shampoos containing apple cider vinegar can also help soothe inflammation on the scalp, says Dr. Yates, who even makes his own.

    Dr. Yates also recommends steering clear of products that contain added fragrance and strong chemicals. He's also "not opposed" to using soothing oils on the scalp that can help calm irritation. And since psoriasis can be triggered by stress, he advises his patients to strive for as healthy and stress-free of a lifestyle as possible.

    Below are the best shampoos for scalp psoriasis, all available on Amazon. But if using an over-the-counter shampoo isn't doing enough to alleviate the psoriasis on your scalp, speak with your dermatologist to discuss short-term topical steroids and other treatment options.

    We only recommend products we love and that we think you will, too. 

    1. Doctor's PickNeutrogena T/Gel Therapeutic Shampoo

                      Neutrogena T/Gel Therapeutic Shampoo

    "One of my favourite OTC shampoos is T/Gel, which contains coal tar," says Dr. Yates. This is a popular drugstore product among people with inflammatory scalp conditions, and it received the National Psoriasis Foundation (NPF) Seal of Recognition, meaning it's intended to be non-irritating and safe for people with psoriasis. Coal tar helps alleviate itching and reduce build-up on the scalp, so it's also helpful for treating things like dandruff.

    Do be aware that coal tar can temporarily discolour lighter-coloured hair, and it also poses the risk of staining skin or clothing. For best results, leave this shampoo in your hair for a few minutes before rinsing it out thoroughly.

    2. A Shampoo With A Higher Concentration Of Coal TarMG217 Psoriasis Medicated Conditioning 3% Coal Tar Shampoo

                   MG217 Psoriasis Medicated Conditioning 3% Coal Tar Shampoo

    Another NPF-approved shampoo, MG217 Psoriasis Medicated Conditioning Shampoo contains a higher concentration of coal tar than Neutrogena T/Gel (3% compared to T/Gel's 0.5%), so it's a bit more heavy duty. Use it to help relieve itching, redness, and flaking on your scalp. If you find that your OTC psoriasis shampoos are too drying, you can alternate them with a non-medicated shampoo every other time you wash your hair.

    3. A Shampoo With Salicylic Acid

    Dermarest Psoriasis Medicated Shampoo & Conditioner (2-Pack)
       Dermarest Psoriasis Medicated Shampoo & Conditioner (2-Pack)

    This medicated shampoo from Dermarest (yes, it also has the NPF seal) contains the other known effective ingredient for treating scalp psoriasis: salicylic acid, which works by removing scalp buildup and can thereby help relieve redness and itching. It comes with a matching conditioner, too, both for under $15 on Amazon.

    4. A Shampoo With Apple Cider Vinegar

    Aveeno Scalp Soothing Apple Cider Vinegar Blend Shampoo
              Aveeno Scalp Soothing Apple Cider Vinegar Blend Shampoo

    If you prefer milder ingredients to the more heavy-duty options above (or want another shampoo to alternate with your coal tar/salicylic acid shampoo), try Aveeno's Scalp Soothing Apple Cider Vinegar Blend Shampoo. In addition to the clarifying apple cider vinegar, it contains skin-soothing oats, and has a fresh, pleasant scent, unlike most medicated shampoos. That said, if your skin has a known sensitivity to fragrance, this may not be the best choice for you.

    Also Consider:

    OKAY 100% Pure Coconut Oil


                    OKAY 100% Pure Coconut Oil

    If your scalp is super dry, that can exacerbate itching and irritation, which is why Dr. Yates says it's fine to use soothing oils to replenish moisture on your scalp. For example, apply this 100% pure coconut oil as a leave-in treatment. Not only will it restore moisture to your hair and scalp, which may be dry from your medicated shampoos, but it can also be used all over your body.

    Expert:

    Dr. William Yates, M.D. F.A.C.S., a board-certified hair loss expert based in Chicago, IL.

    https://www.elitedaily.com/p/the-4-best-shampoos-for-psoriasis-35296816 

    Wednesday, 14 October 2020

    How your oral health can prevent psoriasis

    From wmcactionnews5.com

    COLUMBUS, Ohio. (Ivanhoe Newswire) -- About seven and a half million Americans have psoriasis and about 40% of those patients also have joint inflammation that produces painful arthritis symptoms. Now, new research suggests one surprising potential cause for the condition and some preventive measures patients can take.

    For years Douglas Levin struggled with psoriatic arthritis.

    Eventually, Levin adopted a healthier lifestyle to help counter the inflammation caused by his disease.

    “Anytime you can control it by moderating your intake of food or other things you’re that much better off,” shared Levin.

    Researchers know that a problem with the immune system can trigger psoriasis. Now, Ohio State medical dermatologist Benjamin Kaffenberger is studying a potential link between poor oral health, bacterial infections in the mouth and psoriasis.

    “When your body is attempting to fight this bacteria, probably it develops a little bit of a cross-reaction with the skin at the same time,” explained Kaffenberger.

    Researchers surveyed 100 patients with psoriasis, and 165 without psoriasis about their lifestyle and diet. The results showed that poor dental and oral health, especially gum pain was associated with psoriasis.

    “Unfortunately, a lot of patients don’t have good access to dental care, or maybe just are too busy at a certain time frame. So, they may not be getting that message when they have this disease in the first place,” said Kaffenberger.

    Patients who had higher fruit consumption reported less significant psoriasis. Researchers say that indicates fresh foods may be a protective factor. For Levin, lifestyle changes mean psoriasis no longer controls his life or his time outdoors with his good boy.

    The Ohio State University study also reinforced earlier studies that found a family history of psoriasis, smoking and obesity could be predictors of the condition.

    https://www.wmcactionnews5.com/2020/10/13/best-life-how-your-oral-health-can-prevent-psoriasis/

    Sunday, 11 October 2020

    What's the Difference Between Psoriatic Arthritis and Rheumatoid Arthritis?

    From self.com

    If you’ve got sore, swollen joints, there’s a good chance you’ll come across arthritis as you’re searching for a cause of your symptoms. But finding the right treatment requires you to get a lot more specific than that. Arthritis is actually an umbrella term for more than 100 different conditions, according to the Centres for Disease Control and Prevention (CDC). And there are at least two types that might be responsible for your tender, achy joints: psoriatic arthritis and rheumatoid arthritis.

    Even though they have some overlapping symptoms, the two conditions are decidedly different. Here’s what you need to know about psoriatic arthritis and rheumatoid arthritis.

    Psoriatic arthritis and rheumatoid arthritis are both chronic inflammatory conditions.

    With both diseases, an overzealous immune system mistakenly attacks healthy cells in your body. That, in turn, can result in joint pain, stiffness, and swelling, along with perpetual fatigue and other symptoms more specific to either disease. 

    The causes of psoriatic arthritis and rheumatoid arthritis are still up in the air, but doctors suspect the diseases have an underlying genetic component that may make a person more susceptible to certain environmental triggers.

    In any case, psoriatic arthritis and rheumatoid arthritis are both lifelong diseases that can occur in flares (times when symptoms are especially aggravated). And while there’s no cure for either disease, treatments for both psoriatic arthritis and rheumatoid arthritis have come a long way toward keeping symptoms at bay, sometimes even putting the disease into remission. Plus, the right medication can help protect your body from the permanent damage these conditions can cause if left untreated, so it’s important to work with your doctor to manage your disease.

    Psoriatic arthritis often affects people who have psoriasis.

    Having psoriasis, a disease that often causes inflamed, scaly patches of skin on areas like your knees, elbows, and scalp, puts you at greater risk of getting psoriatic arthritis down the road. The Cleveland Clinic estimates that up to 30% of people with psoriasis get diagnosed with psoriatic arthritis. However, it’s possible to get psoriatic arthritis even if you don’t have psoriasis, and vice versa. Psoriatic arthritis affects people of all genders at relatively equal rates and typically shows up in people between the ages of 30 and 50 years old, says the Cleveland Clinic.

    NYU Langone Health explains there are five types of psoriatic arthritis, and depending on which one you have, the disease can show up in very different ways in your body. Around three-quarters of people with the condition have a type called asymmetric oligoarthritis, which impacts up to five joints, though not necessarily the same ones on both sides of the body. When that’s the case, it may be due to symmetric arthritis, a type of psoriatic arthritis that’s similar to rheumatoid arthritis. There’s also spondylitic arthritis, which affects the spine, and distal interphalangeal predominant psoriatic arthritis, which mainly involves the joints near your fingernails and toenails. The rarest form of psoriatic arthritis is arthritis mutilans. It’s a severe form of the disease that can destroy the bones in your hands, per the Mayo Clinic.

    Up to 80% of people with psoriatic arthritis have nail changes, like pitting, crumbling, or grooves and ridges. In addition, foot pain, particularly in the back of your heel or sole, where the tendons and ligaments link up with bones, is common with psoriatic arthritis, as is lower back pain, per the Mayo Clinic.

    The inflammation from psoriatic arthritis can also cause eye problems, such as uveitis. This condition can lead to permanent vision loss, so look out for early warning signs, like eye pain, redness, light sensitivity, and “floaters” blocking parts of your sight.

    Rheumatoid arthritis doesn’t have that psoriasis link.

    The Cleveland Clinic reports that women are diagnosed with rheumatoid arthritis at 2.5 times the rate of men. A common misconception about rheumatoid arthritis is that it’s an elderly person’s disease, but the truth is that it’s often diagnosed between the ages of 20 and 50.

    While rheumatoid arthritis can affect people in different ways, its signature characteristics include tenderness, pain, and swelling in more than one joint, per the CDC. And although psoriatic arthritis may impact different joints on each side of the body, rheumatoid arthritis usually causes more symmetrical symptoms, says David Wanalista, D.O., rheumatologist at Atlantic General Rheumatology. As a progressive disease, it usually worsens with time, starting with the joints between your fingers and hands and toes and feet. The inflammation from rheumatoid arthritis can wear down your cartilage, and without that tissue acting as a shock absorber, your bones can eventually erode and lead to fusion of the joint.

    There are also some other symptoms to know when it comes to rheumatoid arthritis. In particular, you might get firm lumps, known as rheumatoid nodules, around pressure points like your elbows, notes the Mayo Clinic. When the disease flares, it can also come with a low-grade fever. Morning stiffness that lasts more than an hour (but usually a few hours) is especially common in people with rheumatoid arthritis (although it can be a symptom of any inflammatory arthritis), per the Johns Hopkins Arthritis Centre. And as with psoriatic arthritis, rheumatoid arthritis can cause eye problems, according to the Mayo Clinic. This may include dryness, redness, and pain.\

    Treatment for psoriatic arthritis and rheumatoid arthritis is similar, but figuring out which disease you have can be tricky.

    No single test can diagnose rheumatoid arthritis or psoriatic arthritis, reports the Mayo Clinic. Rather, your doctor will check your medical history and closely examine your symptoms to see if you have signs of either disease. Symptoms like ongoing morning stiffness, swelling of three or more joints (especially the wrist, hand, or fingers) on the same sides of the body for at least six weeks, and rheumatoid nodules may make your doctor suspect rheumatoid arthritis, the Cleveland Clinic says. To diagnose psoriatic arthritis, your doctor will likely examine your joints to search for swelling and stiffness, fingernails for any issues like pitting, and feet for soreness, according to the Mayo Clinic.

    “[Diagnosis] is very much an art, and the skills and experience of a rheumatologist are necessary,” John M. Davis III, M.D., M.S., a clinical rheumatologist, vice chair and practice chair of the division of rheumatology and associate professor of medicine and the Mayo Clinic College of Medicine and Science, tells SELF. “There is a great need for more sensitive and specific diagnostic tests.”

    Certain medical tests available now can help inform a doctor’s diagnosis. Elevated levels of proteins involved with immune cells may also help a doctor determine whether you have psoriatic arthritis or rheumatoid arthritis (though the results won’t say for sure), the Mayo Clinic says. Arthur Kavanaugh, M.D., associate professor of medicine and rheumatologist at UC San Diego Health, tells SELF that around 85% of people with rheumatoid arthritis have positive antibody tests for rheumatoid factor antibodies, among other blood test results, compared with just 15% of people with psoriatic arthritis with similar blood test results.

    Your doctor may also order imaging tests, like X-rays and MRIs, to help determine if you have psoriatic arthritis. Keep in mind though that certain symptoms and test results don’t show up in everyone with these diseases, and may also overlap with other conditions, making it a challenge to get a firm diagnosis.

    Regardless of the diagnosis, though, you may be exploring some of the same treatment options for either disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), like Advil and Aleve, are often the starting point for treatment of rheumatoid arthritis and psoriatic arthritis. Doctors may also use disease-modifying anti-rheumatic drugs (DMARDs) to slow the progression of either disease, according to the Mayo Clinic. A newer type of medication known as a JAK inhibitor, a special kind of DMARD, may help calm inflammation and prevent joint damage. Biologics may curb inflammation as well. The exact drugs your doctor prescribes from these classes of medicines may vary depending on whether you have psoriatic arthritis or rheumatoid arthritis, particularly when it comes to biologics, says Lisa F. Imundo, M.D., rheumatologist at Columbia University Irving Medical Center.

    It’s important to understand that there’s no one-size-fits-all approach to treating either disease, and how effective a particular medication is can vary from person to person.

    “Treatments can fully restore function and wellbeing in some people, whereas that is more difficult to achieve in other people,” Ana-Maria Orbai, M.D., M.H.S., director of the psoriatic arthritis program at Johns Hopkins University School of Medicine, tells SELF.

    Plus, each medication comes with the risk of potential side effects. Weigh out the pros and cons of each option with your doctor to help strike the right balance for your long-term health.

    Bottom line: If you’re having joint pain or other symptoms of arthritis, talk to your doctor.

    It’s impossible to pinpoint psoriatic arthritis, rheumatoid arthritis, or any of the other dozens of types of arthritis based on symptoms and an online search alone. But some of these diseases can cause serious long-term damage, so talk to your doctor about a diagnosis and treatment options so you can find relief sooner rather than later.

    https://www.self.com/story/psoriatic-arthritis-vs-rheumatoid-arthritis

    The Difference Gender Makes in Psoriatic Arthritis

    From managedhealthcareexecutive.com

    Research documents that the disease affects men and women differently

    The impact of psoriatic arthritis (PsA) differs widely between genders, several studies show.

    In the most recent research, published online in Modern Rheumatology last month, found that disease activity, physical disability, functional limitation, depression and anxiety scores were higher among women with PsA than among men with the disease. The researchers reported that quality of life and Psoriasis Area and Severity Index (PASI) scores were higher in male patients.

    The study of more than 1,000 patients with PsA at 25 centres in Turkey zeroed in on patients with “axial” PsA, a recognized categorization of PsA that means the disease affects the spine, hips and shoulders in contrast to the “peripheral” PsA, which affects the arms and legs).

    Pain score, fatigue, quality of life, anxiety, depression, and other scores were significantly worse in females than males with axial PsA. However, quality of life was better and PASI scores were worse in men than in women, the research team led by Kemal Nas of Sakarya University.

    “This study has shown that the burden of disease in axial PsA has significant difference between genders. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients,” wrote Nas and his colleagues.

    Kemal Nas
    Kemal Nas

    Nas was the lead author of a previous study exploring gender differences among people with PsA that was also published in Modern Rheumatology. That 2017 study found that women with PsA had higher symptom duration and body-mass indexes than men with the disease.

    “Men with PsA are more likely to have higher PASI scores and longer duration to develop arthritis after the onset of psoriasis, while women are more likely to have higher disease activity and report more fatigue and physical activity limitations,” says the abstract.

    Not all of Nas’ findings have pointed to differences between the sexes. In the 2017 study, for example, Nas and his colleagues found that that quality of life, extra-articular features (including uveitis and iritis), family history of PsA and the rates of spondyloarthritis and ankylosing spondylitis were very similar among both men and women.

    https://www.managedhealthcareexecutive.com/view/the-difference-gender-makes-in-psoriatic-arthritis

    Identifying the Trigger for Psoriatic Arthritis

    From ajmc.com

    New research may have identified the trigger that activates psoriatic arthritis in patients, according to a study published in Nature Communications

    Psoriatic arthritis (PsA) is a complex disease that involves multiple inflammatory pathways and develops in approximately one-third of patients with psoriasis. However, not only is there no cure for PsA, but it isn’t understood what triggers the onset of PsA.

    New research may have identified the trigger that activates PsA in patients, according to a study published in Nature Communications. The researchers used single-cell technology to analyse thousands of immune cells obtained from patients with PsA.

    “Our data suggest that psoriatic arthritis doesn’t just appear out of nowhere,” author Hussein Al-Mossawi, BMBCh, MRCP, DPhil, honorary research associate at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) at the University of Oxford, said in a statement.

    Al-Mossawi and his colleagues were able to use the technology to see which genes were switched on in each cell, which showed that the T cells had an activated inflammatory profile. They found that many T cells in the joint fluid they obtained from patients shared an identical T cell receptor—they were clones of each other. The clones of the T cells also shared other markers, including a receptor called CXCR3.

    “Each receptor is like a unique lock that recognizes a molecular key and we discovered, that across the patients, they are recognizing a common molecule,” Al-Mossawi said. “This gives the first evidence that the T cells are seeing and reacting to the same molecule, which acts as a trigger for the disease. We don’t know the exact culprit yet, but this a great step forward in understanding the disease.”

    The study showed increased CXCR3 gene expression, and the authors suggested that CXCR3+ T cells may play “a central role in executing localised inflammation in PsA, and thus represent an attractive therapeutic target.”

    “Our findings indicate that specific T cells are likely to be targeted to enter the joint, where they are triggered to expand, creating inflammation and causing psoriatic arthritis,” said Paul Bowness, BMBCh, DPhil, professor of experimental rheumatology at NDORMS at the University of Oxford. “The next stage of research will be to find the key that is unlocking the disease in patients—from the signals that direct cells to the joint, to what then triggers them to expand. If we can understand these, we could move towards creating therapies that would prevent this, potentially providing a cure.”

    https://www.ajmc.com/view/identifying-the-trigger-for-psoriatic-arthritis