Saturday, 10 May 2025

Why Dermatologists Love At-Home UVB Light for Psoriasis

From healthcentral.com

Clearer skin and fewer office visits are just some of the perks. Discover how UVB therapy works at home 

There are a ton of treatments out there for psoriasis, like topical creams, oral medications, and biologics. But few are as effective (or easy) as ultraviolet B (UVB) light therapy at home, which offers a more accessible way to use phototherapy—the use of a specific wavelength of light to help heal the skin—to treat a host of skin conditions, including psoriasis.

                                                             GettyImages/Science Photo Library

A Brief History of Healing Light

It’s not exactly new. UV light has been used since ancient Egypt to manage skin diseases, and in the early 1900s, the Nobel Prize was awarded to researcher Niels Finsen of Copenhagen for his development of medical phototherapy. More recently, in the 1980s, “we figured out that there’s a single wavelength of light, 311 nanometers, which is very effective at treating psoriasis—yet less likely to cause some of the harmful effects that you may see with other wavelengths that exist in sunlight,” says Joel Gelfand, M.D., a board-certified dermatologist and the medical director of the Psoriasis and Phototherapy Treatment Center at the University of Pennsylvania in Philadelphia.

The Biggest Barrier: Getting to the Dermatologist's Office (Again and Again)

Phototherapy has long been considered an effective way to treat psoriasis, especially compared to other common treatment options. In fact, one review found that it led 75% of people to achieve a status of “clear/minimal disease” with fewer topical treatments, such as steroid creams, for at least 12 months.

But access has been a huge issue, since individuals often must go to the doctor’s office two or three times a week for their phototherapy. “The treatments are [on average] a few minutes long, but to do it two or three times a week for eight to 12 weeks is really hard for a lot of people,” says Dr. Gelfand. Plus, he adds, your health insurer might view each session as a doctor visit and therefore charge a copay every time.

For those reasons, among others, the prospect of doing UVB light therapy at home is appealing—and becoming more common as the effectiveness of such at-home devices improves. In a 2024 study in JAMA Dermatology, of which Dr. Gelfand was the lead author, at-home phototherapy was as effective as the in-office treatment for people with plaque psoriasis. New York board-certified dermatologist Shari Lipner, M.D., a professor at the New York-Presbyterian Hospital/Weill Cornell Medical Center in New York City, also recommends them—especially for “some patients with psoriasis who may have trouble getting to the office during their school or workday,” she says.

What to Expect During At-Home Light Therapy for Psoriasis

At-home UVB light therapy might sound high-tech, but it’s surprisingly straightforward once you get the hang of it. Most people use a handheld or table-top narrowband UVB device that emits a targeted beam of light to treat psoriasis-affected areas. These machines come in different sizes—some are about the size of a shoebox; others resemble oversized flashlights—so you can either hold it directly over a patch of skin or rest it on a stand or table for hands-free treatment.

For larger surface areas or more severe psoriasis, some patients may use full-body panels or even walk-in booth-style units (similar to a tanning booth), though those are less common for home use. The distance between your skin and the light matters: typically, you’ll need to be about a foot away, but your doctor will provide exact instructions based on the device.

You’ll usually do treatments two to three times a week, for sessions ranging from 30 seconds to 15 minutes depending on your dose and skin type. Clothing is optional—many people expose only the areas being treated and keep the rest of their body covered for protection. The device is programmed to match your skin tone—whether fair, medium, or dark—and automatically adjusts the dose accordingly.

How do you know it’s working? According to Dr. Gelfand, a little redness about six hours after treatment that fades within 24 hours is a sign you’ve hit the sweet spot for effectiveness.

How Does UVB Light Therapy Work?

UVB light therapy can target specific areas on the body, which is why the ideal candidate is someone who has psoriasis on the arms, the legs, and/or the trunk, says Dr. Gelfand. It’s not as effective for areas like the scalp, genitals, or nails, where the light doesn’t penetrate as well. Done properly, light therapy offers a lot of benefits for skin. These include:

  • Slows skin cell growth. Psoriasis causes abnormally rapid skin cell turnover, leading to plaque formation. Broadly speaking, UVB light therapy “has an impact on the ability for the skin to proliferate rapidly,” says Dr. Gelfand. “It slows that down.”

  • Tames inflammation. UVB light seems to prevent something called “antigen presentation,” which occurs in conditions like eczema and psoriasis. In these conditions, the immune system mistakenly attacks normal proteins. UVB light therapy helps knock out the cells that trigger this immune response.

  • Restores skin colour. Having psoriasis may increase your risk of developing vitiligo because both are autoimmune conditions that can share similar genetic and immune system pathways. In vitiligo, the immune system attacks melanocytes—the cells that give skin its pigment. Research shows that UVB light can restore pigment by encouraging melanocytes to return to affected areas.

  • Boosts vitamin D. Vitamin D is a go-to treatment for psoriasis, but your body needs sunlight to make it. UVB phototherapy seems to do the trick, too. One study found that light therapy not only increased vitamin D levels but also improved skin clarity among people with psoriasis.

How to Choose the Best UVB Light Therapy Device for Home Use

If you’re looking to try UVB light therapy at home, talk with your doctor first. “This really has to be done under supervision of a physician, preferably a dermatologist,” says Dr. Gelfand. “Most clinicians out there do not get the medical training necessary to diagnose and treat these types of disorders, nor do they have a strong background training of how to use ultraviolet lights effectively.”

Next, you’ll need a machine. You’ll find them in various sizes—handheld wands for small spots or full panels for larger body areas. Any reputable brand (Dr. Gelfand points to Phothera as a good one) will require a doctor’s sign-off in order to purchase. Avoid buying devices online without a prescription; the machines must be carefully calibrated to deliver safe, effective treatment.

What About Cost?

“The biggest barrier patients face is an uneven coverage of these devices by insurance,” says Dr. Gelfand. Sometimes they’re covered; sometimes not. Still, if you find phototherapy works for your psoriasis, it may be worth the investment: One study found phototherapy to be significantly more affordable than biologic treatments—averaging about $5,000 over three years, including bulb replacements compared to a single biologic injection that can cost $3,000 to $10,000.

Is At-Home Light Therapy Safe?

UVB light therapy at home is considered safe, especially because the devices come with built-in safeguards, and your doctor will program the right settings for your skin type.

In fact, in the JAMA Dermatology study, “no one had a severe-enough reaction to the light treatment that they decided to stop phototherapy,” says Dr. Gelfand. Still, it’s smart to be aware of potential side effects:

  • Burns. Possible but rare. “It’s pretty difficult to dose yourself in a way that you could have a medically significant burn because of how the machines are calibrated,” says Dr. Gelfand.

  • Skin cancer risk. While unlikely, long-term UV exposure could slightly raise the risk of skin cancer, especially in fair-skinned individuals. Dr. Gelfand recommends keeping unaffected skin covered—for example, roll up your sleeve to treat a forearm but keep the rest of your body protected. 

Bottom Line

UVB light therapy—especially at home—is one of the most promising treatments for people with psoriasis and other skin conditions. It can be life-changing, with some people reaching remission after just one course of treatment, says Dr. Gelfand.

Even if light therapy alone doesn’t do the trick, it’s an excellent first-line option. “Sometimes we combine therapies—we may add certain oral medications, we may add some of the newer topicals that can be very effective, or they may have to shift to some of the biologics,” he says.

And the best part? You can do it on your own time, in your own home—making it an empowering, flexible tool for managing chronic skin conditions.

https://www.healthcentral.com/article/at-home-uvb-therapy?ap=nl2060&rhid=67ec2b8321f52bf01b0cca01&mui=&lid=141093361&mkt_tok=NTQxLUdLWi0yNDMAAAGaROz36KhiopqNHwZwwjSRy-H3B42iWT6NcOFZVe9KqPGKb7iSAe363AjtMlFuYYREossTTQD7fo7ZuENOWPQNh75wvETBeQVpkjjVnD9d9kqBwQ4

Friday, 9 May 2025

Tips for Finding the Best Shoes for Psoriatic Arthritis

From healthcentral.com 

There’s no one right shoe for PsA-affected feet, but these recommendations can help you find the right fit

If you or someone you love is living with psoriatic arthritis (PsA)—a chronic autoimmune disease that causes inflammation of the joints, tendons, and ligaments as well as skin symptoms (psoriasis)—finding the best shoes goes beyond style, fit, and fashion. In fact, the right shoes can help you battle PsA foot pain, swelling, and tenderness. Proper footwear can also make a difference when it comes to inflammation and joint damage.

“The most important component of foot protection in PsA is to control the underlying systemic [body-wide] inflammation with the correct treatment regimen,” says Elizabeth Schulman, M.D., a rheumatologist at Hospital for Special Surgery in New York City. “However, PsA can also have multiple clinical manifestations in the feet and the right footwear can make a significant difference to prevent mechanical strain that can further trigger inflammation and cause joint damage.”

The number one goal: Finding a fit that provides good arch and toe support, says Dr. Schulman. For more guidance on what to look for, start with these expert-backed tips for finding the best footwear for psoriatic arthritis.


Why Footwear Matters for Psoriatic Arthritis

                                                                                          GettyImages/sf1nks

Simply put: Footwear matters because PsA can do a number on your feet. A recent study of 40 people with PsA in Foot and Ankle Surgery found that 95% of the participants observed the disease in their feet. And while symptoms vary from person to person, the study found PsA in the feet can have an impact on quality of life, leading to pain, deformities, and walking and mobility difficulties.

“Foot issues are a huge problem with PsA,” says Jody Quinn, a patient advocate from Plymouth, MA, who was diagnosed with PsA in 2024. “Before I was officially diagnosed, I had plantar fasciitis, which I eventually found out is a common symptom of PsA. I also had swollen toes, commonly called “sausage like digits,” swollen feet, and ankles along with tremendous pain in the many joints in my feet. The feet are definitely an area of the body where PsA pain can strike and can prevent you from enjoying daily activities.”

The disease often attacks the smaller joints in the feet (the distal interphalangeal joints), the ankle, and the entheses, where tendons and ligaments attach to bone. Issues include:

  • Bunions, bony bumps at the base of the big toe, can be painful when the bone presses against your shoes, and affect other toes and ball of the foot, according to the American Academy of Orthopedic Surgeons.

  • Dactylitis (a.k.a. “sausage digits”) can cause foot or toe pain, a feeling of “heat” in the foot, skin discoloration, and difficulty moving or bending your toes, according to the Cleveland Clinic.

  • Enthesitis, or inflammation in the enthesis, can cause pain and burning where the Achilles tendon attaches to the back of the heel and at the plantar fascia ligament, which stretches along the bottom of your foot, causing plantar fasciitis.

  • Hammer/claw toes, caused by damage in joints from chronic inflammation, can result in changes in shape and alignment of the toes.

  • Pitting, or shallow or deep holes in the nail plate, often start as a cosmetic issue but can lead to thickening of the toenails or infection due to pressure on the nail bed.

The good news: If caught early, many of these foot issues can be prevented and treated with simple self-care, including investing in the right shoes. “Ideally you care for your feet the way you care for your other body parts,” says Dr. Schulman. “Our feet bear the pressure from the rest of our body so proper hygiene, foot support, rest, and strengthening are key.”


Tips for Buying the Best Shoes for Psoriatic Arthritis

The best shoe for PsA will largely depend on your individual symptoms, so it’s best to check with your rheumatologist or podiatrist for guidance.

That said, both experts and people living with PsA agree that good arch and ankle support, a supportive heel counter (for shock absorption), and a wide and deep toe box are must-haves. “Unsupportive footwear can put extra strain on the ligaments, bones, joints, and tendons leading to worsening inflammation and overtime damage,” says Dr. Schulman.

Sari Priesand, D.P.M., a clinical assistant professor at the University of Michigan in Ann Arbor and spokesperson for the American Podiatry Medical Association (APMA), suggests looking for shoes with the APMA Seal of Acceptance and Seal of Approval, which are reviewed by a group of APMA podiatrists to ensure foot health.

Get Professionally Fitted

Since everyone’s feet are a little different, it’s best to get expert guidance to measure for supportive footwear for PsA, says Dr. Schulman. A proper in-store fitting can make a big difference—and may just become a regular part of your shoe-buying routine. After all, sizing varies among manufacturers and the location of PsA inflammation can change quickly.

If possible, invest in a couple of options based on your daily activities to be sure you’re always as comfortable and supported as possible. For example, Quinn tends to wear clogs to prevent heel pain when her plantar fasciitis flares and boots with a cushioned footbed in the fall and winter to support her ankle and reduce the swelling that often develops during colder weather.

When shopping for shoes, keep in mind that your feet tend to swell throughout the day, so it’s best to schedules fittings later in the day when swelling is more significant, rather than in the morning when feet tend to be less swollen, says Dr. Priesand.

Shop for Shoes with Removable Insoles

Comfort often starts by removing the factory insoles and replacing them with customized orthotics to better support your feet and correct any deformities. Your podiatrist can evaluate your pain points and gait (the pattern of how you walk), and fit you for insoles or orthotics or even create something custom for you. Some insurance companies will cover the cost of customized ones. If not, ask your doctor for an over-the-counter recommendation.

Opt for Lightweight Options

When you pick up a shoe, it should feel light in your hand. Lightweight shoes can help reduce joint fatigue and make day-to-day walking easier. A heavy shoe, on the other hand, will make it harder to lift your foot off the ground, increasing joint strain and potentially altering your gait. “Lightweight doesn’t mean minimalist,” warns Dr. Priesand. Lightweight shoes still need to be supportive. A good test for support: Try to bend the shoe in half. It should only bend at the forefront where the toe bends naturally.

Say Yes to Slip-Resistant Soles

The swelling, inflammation, and deformities that occur with PsA in your feet can change the way you walk, increasing your risk of falls. To help you stand and move around safely, say no to slippery leather soles and instead go for rubber ones or those with a secure grip built into the sole.

Consider Finger-Friendly Footwear

Psoriatic arthritis can cause stiffness and reduced range of motion in the fingers and wrists. If PsA affects your hands, consider Velcro closings or elasticized laces so you can easily slip into your shoes.

Look for Soft and Flexible Uppers

Dr. Priesand suggests looking for shoes with soft, flexible uppers, including materials like neoprene, mesh, or knit fabric, to accommodate any swelling, toe deformities, or skin issues. “Avoid leather because it’s not very forgiving—it doesn’t allow for much movement, which can be harmful,” she says.

When someone with PsA has swollen toes from dactylitis, wider toe boxes and more flexible materials can help prevent excess pressure and avoid stress on the foot, adds Dr. Schulman.

Pay Attention to Heel Height

Overall, it’s best to avoid heels higher than two inches, notes the APMA. More than that and it may affect your balance and stability. High heels also put extra pressure on the arches and stress on joints. If you want a little lift, kitten heels (less than one inch) are the most foot-friendly, especially if they have a generous toe box area and extra cushioning at the front of the shoe.

Test Them Out

Even the best shoes for psoriatic arthritis have to be broken in slowly. Dr. Priesand recommends wearing them for an hour the first day and then increasing by an hour a day for the first week. Check for red spots on your skin and note how your feet feel as they swell throughout the day.

And once you find the right fit, remember to periodically assess the sole for wear and tear—it’s a sign that it’s time to change them or discuss any patterns with your podiatrist, says Dr. Priesand.

“I would recommend replacing shoes every six to 12 months or whenever there are signs of wear,” adds Dr. Schulman.

Alert Your Doctor to Foot Symptoms

If you notice any new or worsening symptoms in your feet, your first step should be to talk to your doctor. Changes in the toes can be a sign that your PsA is advancing or not well-controlled, informing your treatment decisions. “Many people tend to ignore their foot and ankle symptoms until they are severe and preventing ambulation,” warns Dr. Schulman.

Here are a few signs of PsA in your toes and your feet:

  • Pain when bending your toes

  • Swollen digits

  • Tendon attachment pain

  • Toenail changes (thickening or lifting of toenails or pitting)

https://www.healthcentral.com/condition/psoriatic-arthritis/best-shoes-for-psoriatic-arthritis 

Wednesday, 7 May 2025

How Are Injections Used to Treat Psoriasis?

From healthcentral.com

Learn about potential benefits, drawbacks, and which treatments delivered via a shot may be right for managing severe symptoms 

Psoriasis is a full-body, autoimmune condition that often appears on the skin as dry, flaky patches, referred to as plaques. It can sometimes be managed with topical treatments, but more severe cases often required advanced therapies such as biologic medications. Biologics used to treat psoriasis are often given by injections, either at home or in a clinical setting. Depending on your insurance, biologics can be an expensive choice of treatment but may also be well worth the cost.

Most experts agree: Biologics have been a game changer for psoriasis treatment, says Kurt Ashack, M.D., a dermatologist at Dermatology Associates of West Michigan in Grand Rapids, MI. “Biologics last in the body for longer, and that keeps the psoriasis at bay for much longer,” he says. Wondering exactly what biologics are and how injections for psoriasis work? Our experts break it all down here, including how injections have become a new standard level of care for those with moderate to severe psoriasis.

                                                                  GettyImages/Catherine Falls Commercial

What Are Biologics?

Not long ago, traditional medications used to treat psoriasis impacted the entire immune system. Biologic medications are different from those older medications, quieting only a portion of the immune system that is overactive because of psoriasis. The Food and Drug Administration has approved at least 11 different biologics to treat psoriasis. At least one of the medications, infliximab, requires an infusion (through an IV) but the others can be received by an injection. “The injections aren’t very painful, and they range from one shot a month to 4 shots a year,” says Dr. Ashack.

According to the National Psoriasis Foundation, the biologics that are used to treat psoriatic disease block proteins in the immune system including tumour necrosis factor-alpha (TNF-alpha), interleukins 12 and 23, and interleukin 17. Let’s take a closer look at each.

TNF-Alpha Inhibitors

According to the journal Clinical Immunology, more than a million people worldwide have been treated with tumour necrosis factor-alpha (TNFα) inhibitors for a variety of conditions including rheumatoid arthritis, inflammatory bowel disease, and psoriatic disease. TNF-alpha inhibitors help reduce pro-inflammatory cytokines that increase inflammation through several pathways. Blocking the TNF-alpha production helps stop the inflammation related to psoriatic disease. Some of the TNF-alpha inhibitors approved for psoriasis include:

  • Cimzia (certolizumab pegol)

  • Enbrel (etanercept)

  • Humira (adalimumab)

  • Remicade (infliximab)

  • Simponi (golimumab)

  • Simponi Aria (golimumab)

IL-12/23 Inhibitors

“This injectable biologic works by selectively targeting the proteins, or cytokines, interleukin 12 (IL-12) and interleukin 23 (IL-23),” says Adam Kaye, Pharm.D., a clinical professor of pharmacy at the University of the Pacific in Stockton, CA. Stelara (ustekinumab) is the biologic that is approved for psoriasis and targets both the IL-12 and IL-23 pathways, he says. “When patients take this biologic, they will take an initial dose subcutaneously (under the skin), followed by a second dose at week four, then every 12 weeks after the initial dosing,” he explains. Interleukins 12/23 are associated with psoriasis inflammation.

IL-17 Inhibitors

Interleukin 17 is also associated with psoriatic disease. According to Kaye, there are several approved IL-17 inhibitors used to treat psoriasis including:

  • Cosentyx (secukinumab)

  • Taltz (ixekizumab)

  • Siliq (brodalumab)

The latest in this class to be approved is Bimzelx (bimekizumab-bkzx). Kaye says the most common adverse effects of this class of medication is infection risk. Each of the IL-medications for psoriasis are taken subcutaneously by injection, explains Kaye.

IL-23 Inhibitors

Kaye says there are three main interleukin 23 inhibitors used for psoriasis: Tremfya (guselkumab), Ilumya (tildrakizumab), and Skyrizi (risankizumab). These biologics are used for both psoriasis and psoriatic arthritis. According to the National Psoriasis Foundation, IL-23 inhibitor medications can treat psoriatic disease and also help slow psoriatic disease progression. According to Kaye, a common adverse effect of IL-23 inhibitors is an increased risk of infection.

Does Methotrexate Treat Psoriasis?

Methotrexate, approved in 1972 for psoriasis treatment, is still prescribed in some circumstances, especially if cost is an issue. Methotrexate is usually taken as a pill and works more broadly compared to the biologic medications to dampen an overactive immune system. According to the American Academy of Dermatology Association, most patients who are prescribed methotrexate, see less symptoms from psoriasis in four to six weeks. However, according to Kaye, methotrexate isn’t for everyone, because it comes with potentially serious side effects. “Methotrexate is a medication with well-known pulmonary and liver risks that clinicians are well aware of and know they need to monitor for,” he explains.

Possible Medication Side Effects

Dr. Ashack says that while all immunosuppressant medications can make you an easier target for infections, your immune system takes less of a hit on a biologic as compared to methotrexate. “The targeted therapies for psoriasis like Skyrizi and Tremfya are so specific to psoriasis that the body does not utilize this pathway for a lot of other things like fighting off infections,” he says. Still, “biologics do cause an increased risk in infection, but they are much safer than older therapies like methotrexate.”

Kaye agrees and says that the newer targeted medication side effects can be subtle, but something to still be aware of. The need to avoid infections due to immunosuppressive therapies is a basic philosophy that should be shared with patients by the prescriber when biologic therapy begins, he adds.

Other Treatment Options

Especially for mild psoriasis, there are other treatment options to try before biologics. Topical therapies such as moisturizing lotion, steroid cream, medicated shampoo, vitamin D ointment, and retinoid cream are all effective options for some people with milder forms of the disease, per the Cleveland Clinic.

But if you have more severe psoriasis, or your psoriasis isn’t improving with your existing treatment, it may be time to talk to your dermatologist about a new approach. “Injectable biologics often make the psoriasis melt away so that you don’t have to use your topical therapy anymore, or if so, very little,” Dr. Ashack reports.

Bottom Line on Psoriasis Injections

In recent years, new medications called biologics have been approved to treat moderate to severe psoriasis. These medications target different specific parts of the immune system. Because they are so targeted, they are often very effective and avoid suppressing your entire immune system.

These medications are usually taken several times a year by injection. While effective, biologic medications can be unaffordable for some. While biologics are more targeted, they still have potential side effects, and you will need to maintain close communication with your provider when taking a biologic medication. According to the American Academy of Dermatology Association, if you are prescribed a biologic, you should contact your doctor if you have any side effects, stop taking the medication, have difficulty with the injection, or plan to become pregnant.

https://www.healthcentral.com/condition/psoriasis/psoriasis-injections?ap=nl2060&rhid=67ec2b8321f52bf01b0cca01&mui=&lid=141093361&mkt_tok=NTQxLUdLWi0yNDMAAAGaROz36BjyJ8WYxwi4iTV0lfhMzwiZ2LGE5Ie4izo9xiksy5oA0-w0hbnHFJrb50i63E4ka80xZtmK2GO3LZFCsIN2KlYzD_YX2bnUIEWbLQDZ6ZA

Tuesday, 6 May 2025

Beyond Psoriasis: Living Through the Flares

From health.com

India Bolton, 25, doesn't always have visible psoriasis flares. But there are times when her psoriasis becomes so severe that she barely feels like herself. Below, she shares how she's learned to manage the condition, how she's improved her confidence, and who serves as her biggest source of support.


There was a time when it was hard to think about anything but psoriasis.

Last year, during my pregnancy with my son, I had the worst flare I’ve ever experienced. I broke out in guttate, inverse, and plaque psoriasis from head to toe. It lasted for seven months.

For those seven months, I didn’t feel like myself. The pain was constant. I couldn’t be present for my kids the way I wanted to be. When it hurts just to wear clothes, running around and playing isn’t really an option.

With guidance from my dermatologist and rheumatologist, I began UVB treatment twice a week—a therapy considered safe during pregnancy. Imagine a giant box that emits a targeted laser, focusing on each spot of psoriasis.

I knew my skin would likely get worse before it got better as part of this process, but I didn’t expect to be covered in blisters along the way. I told myself to trust the process. I held on to the hope that I’d look like myself again. I even remember apologizing to people for being "so ugly."

That mindset began to shift when I created an Instagram account focused on my psoriasis. Suddenly, I was connecting with people who looked like me. At one of the lowest points in my life, it was incredibly validating just to know I wasn’t the only person in the world going through this.

Life With Psoriasis

Gradually, the UVB therapy started to work. I also recommitted to my diet. Years earlier, I’d identified dairy and beef as flare triggers, but I took it further this time. I cut out nightshade vegetables like bell peppers and eggplants. I went gluten-free, which has been the toughest change. It took months, but I truly believe these dietary shifts helped.

I wish I could say eating a psoriasis-friendly diet comes naturally now. But what I can and can’t eat is still constantly top of mind. Lately, I’ve felt frustrated, and I haven’t been as stringent about my restrictions. I just want to live. I’m human. I want to go out to dinner without analysing every single ingredient.

Thankfully, I have an incredible support system that helps me enjoy life whether I’m flaring or not. My partner, Logan, doesn’t think twice about helping me apply lotion when I need it. My friends welcomed me without hesitation. I was so worried they’d see my psoriasis as something disgusting. Instead, they just see me—a normal human being.

One silver lining in all of this is that I’ve been able to teach my children about confidence, especially my two daughters. They get to see that their mom loves herself no matter what her skin looks like.

https://www.health.com/beyond-psoriasis-11725934 

Monday, 5 May 2025

Ultra-processed foods linked to higher psoriasis risk

From news-medical.net/news

New research links ultra-processed food intake to higher psoriasis risk, even after accounting for genetics, BMI, and lifestyle, highlighting the potential of dietary changes in preventing chronic skin conditions 

A recent study published in the journal Nutrients explores the role of ultra-processed food (UPF) consumption on the risk of psoriasis.

What causes psoriasis?

Psoriasis is a chronic skin condition characterized by inflamed, scaly, and itchy patches. Psoriasis lesions are not site-specific; however, this skin condition often affects the palms, soles, and nails. Psoriasis may also increase the risk of mental health issues like depression and anxiety, as well as cardiovascular disease (CVD) and Crohn’s disease.  

Psoriasis affects 2-3% of people worldwide, with the incidence of this condition differing based on geographic regions, ranging between 30 and 321 cases for every 100,000 people. Although there is no cure, several therapeutic approaches, including phototherapy, prescription drugs, and biologic agents, are currently used to manage psoriasis symptoms.

Certain dietary components may induce systemic inflammation, thereby increasing the risk of psoriasis. The consumption of UPFs, for example, is associated with inflammatory allergic conditions, as demonstrated by higher levels of the allergy-associated immunoglobulin E (IgE), childhood asthma, and allergic symptoms in eczema.

What are UPFs?

UPFs are created through various industrial processes to increase the palatability of food products while extending their shelf life. However, the processes and ingredients used to produce UPFs significantly reduce their nutritional profile, as they are often high in sugar, oil, and other additives like emulsifiers and artificial flavours.

                                                                   Image Credit: Ekaterina Markelova / Shutterstock.com

The NOVA system classifies all foods and food products into four groups based on the extent of industrial processing used during their production. Foods in the NOVA group 1 are unprocessed or minimally processed, whereas group 2 includes any ingredients that have undergone industrial processing, such as oils, fats, sugar, and salt, which may be used to prepare, season, and/or cook group 1 foods.

NOVA group 3 includes food products from groups 1 and 2 that have subsequently undergone preservation methods like canning, bottling, or non-alcoholic fermentation. UPFs are classified as NOVA group 4 foods.

UPFs currently contribute to over 50% of the total energy intake in the United States, Canada, and the United Kingdom. This global upward trend continues to rise, as UPF sales in other nations like Australia and Western European countries have also accelerated.  

UPF consumption has been widely studied for its role in increasing the risk of noncommunicable diseases like CVD, type 2 diabetes, and Crohn’s disease. However, it remains unclear how UPF consumption may impact psoriasis development.

About the study

The current study explores differences in the incidence of psoriasis by UPF consumption based on the NOVA classification system. A total of 121,019 study participants between 40 and 69 years of age were included in the analysis.

The researchers determined the association between the risk of new-onset psoriasis and UPF intake and investigated the role of inflammation and body mass index (BMI) in this association.

Study findings

Individuals who consumed more UPFs were more likely to be younger White males with a higher BMI, less habitual physical activity, and a history of current or previous cigarette smoking. The energy intake among these study participants was also higher.

UPF consumption was categorized into four different quartiles, with the first quartile representing the reference or lowest group. After a median follow-up period of 12 years, the risk of psoriasis was 7% higher in the second quartile of UPF intake as compared to the reference group.

The risk of psoriasis continued to rise as UPF consumption rates increased, with a 19% and 23% higher risk reported among individuals in the third and fourth quartiles, respectively. For every 10% increase in UPF consumption, the risk of psoriasis rose by 6%.

Among those with an increased genetic risk of psoriasis, higher UPF intake led to a nearly threefold increased risk of developing psoriasis as compared to those with a low genetic risk and low UPF consumption. After adjusting for age, sex, BMI, smoking and drinking, physical activity, and socioeconomic deprivation, no significant change in these associations was observed.

The Inflammation (INFLA) score contributed to 6.5% of the association between psoriasis risk and UPF intake, whereas BMI mediated 30.5% of this risk.

These observations agree with previous studies reporting increased rates of obesity, which independently increases the risk of psoriasis incidence and severity, associated with UPF consumption. UPF consumption also leads to low-grade dietary and gut inflammation, which is worsened by the concomitant reduction in the consumption of fresh and/or unprocessed foods with anti-inflammatory benefits.

This underscores the crucial role of controlling UPF intake in the primary prevention of psoriasis.”

When UPFs were replaced with category 1 food, the estimated risk of psoriasis was reduced by 18%.

Conclusions

The current prospective study is the first to estimate the incidence of psoriasis in relation to UPF consumption in United Kingdom Biobank participants. Together, these findings indicate a 6% increased risk of psoriasis with each 10% increase in UPF consumption, with this risk reduced by 18% if 20% of UPFs were replaced with category 1 foods.

Increased UPF consumption is associated with a higher risk of psoriasis.”

https://www.news-medical.net/news/20250504/Ultra-processed-foods-linked-to-higher-psoriasis-risk.aspx